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MATLAB_ROOT is optionnal for the ITK code to compile. You may use it if you have matlab on your machine. If matlab is found, it will turn on some unit tests to check some c++ results against matlab ones.
Of course the parts between underscores should be replaced by your own paths. In my case for example I have:
The project has been tested on a linux 32 bits machine, a linux 64 bits machine and an intel mac machine. Compilation was tested on windows XP with visual studio express.
The code that ships with the source package (the results of "make package_source" is released under a BSD licence)