diff --git a/Modules/Registration/Metricsv4/wrapping/itkANTSNeighborhoodCorrelationImageToImageMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkANTSNeighborhoodCorrelationImageToImageMetricv4.wrap
index 0c37b4fe32e..5cf212cb33e 100644
--- a/Modules/Registration/Metricsv4/wrapping/itkANTSNeighborhoodCorrelationImageToImageMetricv4.wrap
+++ b/Modules/Registration/Metricsv4/wrapping/itkANTSNeighborhoodCorrelationImageToImageMetricv4.wrap
@@ -1,3 +1,8 @@
 itk_wrap_class("itk::ANTSNeighborhoodCorrelationImageToImageMetricv4" POINTER)
-itk_wrap_image_filter("${WRAP_ITK_REAL}" 2 2+)
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
+  foreach(t ${WRAP_ITK_REAL})
+    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}I${ITKM_${t}}${d}"
+                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
+  endforeach()
+endforeach()
 itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/itkCorrelationImageToImageMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkCorrelationImageToImageMetricv4.wrap
index d9d91ae24df..760969a0873 100644
--- a/Modules/Registration/Metricsv4/wrapping/itkCorrelationImageToImageMetricv4.wrap
+++ b/Modules/Registration/Metricsv4/wrapping/itkCorrelationImageToImageMetricv4.wrap
@@ -1,3 +1,8 @@
 itk_wrap_class("itk::CorrelationImageToImageMetricv4" POINTER)
-itk_wrap_image_filter("${WRAP_ITK_REAL}" 2 2+)
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
+  foreach(t ${WRAP_ITK_REAL})
+    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}I${ITKM_${t}}${d}"
+                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
+  endforeach()
+endforeach()
 itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/itkDemonsImageToImageMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkDemonsImageToImageMetricv4.wrap
index 8ce08829710..f73d12e6278 100644
--- a/Modules/Registration/Metricsv4/wrapping/itkDemonsImageToImageMetricv4.wrap
+++ b/Modules/Registration/Metricsv4/wrapping/itkDemonsImageToImageMetricv4.wrap
@@ -1,3 +1,8 @@
 itk_wrap_class("itk::DemonsImageToImageMetricv4" POINTER)
-itk_wrap_image_filter("${WRAP_ITK_REAL}" 2 2+)
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
+  foreach(t ${WRAP_ITK_REAL})
+    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}I${ITKM_${t}}${d}"
+                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
+  endforeach()
+endforeach()
 itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/itkImageToImageMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkImageToImageMetricv4.wrap
index 672f8baa183..8580ffdb699 100644
--- a/Modules/Registration/Metricsv4/wrapping/itkImageToImageMetricv4.wrap
+++ b/Modules/Registration/Metricsv4/wrapping/itkImageToImageMetricv4.wrap
@@ -1,8 +1,8 @@
 itk_wrap_class("itk::ImageToImageMetricv4" POINTER_WITH_SUPERCLASS)
-foreach(d ${ITK_WRAP_DIMS})
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
   foreach(t ${WRAP_ITK_REAL})
-    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}"
-                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
+    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}I${ITKM_${t}}${d}"
+                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
   endforeach()
 endforeach()
 itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/itkJointHistogramMutualInformationImageToImageMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkJointHistogramMutualInformationImageToImageMetricv4.wrap
index 31ec99c4805..4656e4c2b2e 100644
--- a/Modules/Registration/Metricsv4/wrapping/itkJointHistogramMutualInformationImageToImageMetricv4.wrap
+++ b/Modules/Registration/Metricsv4/wrapping/itkJointHistogramMutualInformationImageToImageMetricv4.wrap
@@ -1,3 +1,8 @@
 itk_wrap_class("itk::JointHistogramMutualInformationImageToImageMetricv4" POINTER)
-itk_wrap_image_filter("${WRAP_ITK_REAL}" 2 2+)
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
+  foreach(t ${WRAP_ITK_REAL})
+    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}I${ITKM_${t}}${d}"
+                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
+  endforeach()
+endforeach()
 itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/itkMattesMutualInformationImageToImageMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkMattesMutualInformationImageToImageMetricv4.wrap
index 4ec58d4591a..54a0fc18424 100644
--- a/Modules/Registration/Metricsv4/wrapping/itkMattesMutualInformationImageToImageMetricv4.wrap
+++ b/Modules/Registration/Metricsv4/wrapping/itkMattesMutualInformationImageToImageMetricv4.wrap
@@ -1,3 +1,8 @@
 itk_wrap_class("itk::MattesMutualInformationImageToImageMetricv4" POINTER_WITH_2_SUPERCLASSES)
-itk_wrap_image_filter("${WRAP_ITK_REAL}" 2 2+)
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
+  foreach(t ${WRAP_ITK_REAL})
+    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}I${ITKM_${t}}${d}"
+                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
+  endforeach()
+endforeach()
 itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/itkMeanSquaresImageToImageMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkMeanSquaresImageToImageMetricv4.wrap
index a6cea246c65..cda92fa4119 100644
--- a/Modules/Registration/Metricsv4/wrapping/itkMeanSquaresImageToImageMetricv4.wrap
+++ b/Modules/Registration/Metricsv4/wrapping/itkMeanSquaresImageToImageMetricv4.wrap
@@ -1,3 +1,8 @@
 itk_wrap_class("itk::MeanSquaresImageToImageMetricv4" POINTER_WITH_2_SUPERCLASSES)
-itk_wrap_image_filter("${WRAP_ITK_REAL}" 2 2+)
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
+  foreach(t ${WRAP_ITK_REAL})
+    itk_wrap_template("${ITKM_${t}}${d}${ITKM_${t}}${d}I${ITKM_${t}}${d}"
+                      "itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >, itk::Image< ${ITKT_${t}}, ${d} >")
+  endforeach()
+endforeach()
 itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/itkObjectToObjectMultiMetricv4.wrap b/Modules/Registration/Metricsv4/wrapping/itkObjectToObjectMultiMetricv4.wrap
new file mode 100644
index 00000000000..7c78db75c43
--- /dev/null
+++ b/Modules/Registration/Metricsv4/wrapping/itkObjectToObjectMultiMetricv4.wrap
@@ -0,0 +1,7 @@
+itk_wrap_class("itk::ObjectToObjectMultiMetricv4" POINTER)
+foreach(d ${ITK_WRAP_IMAGE_DIMS})
+  foreach(t ${WRAP_ITK_REAL})
+    itk_wrap_template("${d}${d}I${ITKM_${t}}${d}" "${d},${d},itk::Image< ${ITKT_${t}}, ${d} >")
+  endforeach()
+endforeach()
+itk_end_wrap_class()
diff --git a/Modules/Registration/Metricsv4/wrapping/test/CMakeLists.txt b/Modules/Registration/Metricsv4/wrapping/test/CMakeLists.txt
index 636c94952b6..9469407c001 100644
--- a/Modules/Registration/Metricsv4/wrapping/test/CMakeLists.txt
+++ b/Modules/Registration/Metricsv4/wrapping/test/CMakeLists.txt
@@ -59,6 +59,11 @@ if(ITK_WRAP_PYTHON)
     EXPRESSION "instance = itk.MeanSquaresImageToImageMetricv4.New()"
   )
 
+  itk_python_add_test(
+    NAME itkObjectToObjectMultiMetricv4PythonTest
+    COMMAND ${CMAKE_CURRENT_SOURCE_DIR}/itkObjectToObjectMultiMetricv4Test.py
+  )
+
   itk_python_expression_add_test(
     NAME itkPointSetToPointSetMetricv4PythonTest
     EXPRESSION "instance = itk.PointSetToPointSetMetricv4.New()"
diff --git a/Modules/Registration/Metricsv4/wrapping/test/itkObjectToObjectMultiMetricv4Test.py b/Modules/Registration/Metricsv4/wrapping/test/itkObjectToObjectMultiMetricv4Test.py
new file mode 100644
index 00000000000..08d735113c1
--- /dev/null
+++ b/Modules/Registration/Metricsv4/wrapping/test/itkObjectToObjectMultiMetricv4Test.py
@@ -0,0 +1,48 @@
+# ==========================================================================
+#
+#   Copyright NumFOCUS
+#
+#   Licensed under the Apache License, Version 2.0 (the "License");
+#   you may not use this file except in compliance with the License.
+#   You may obtain a copy of the License at
+#
+#          https://www.apache.org/licenses/LICENSE-2.0.txt
+#
+#   Unless required by applicable law or agreed to in writing, software
+#   distributed under the License is distributed on an "AS IS" BASIS,
+#   WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+#   See the License for the specific language governing permissions and
+#   limitations under the License.
+#
+# ==========================================================================
+
+import itk
+
+# Test with float images
+Dimension = 2
+ImageType = itk.Image[itk.F, Dimension]
+
+# Test basic instantiation
+multi_metric = itk.ObjectToObjectMultiMetricv4[Dimension, Dimension, ImageType].New()
+assert multi_metric is not None
+
+# Create a simple metric to add - now with explicit TVirtualImage
+ms_metric = itk.MeanSquaresImageToImageMetricv4[ImageType, ImageType, ImageType].New()
+assert ms_metric is not None
+
+# Add metric to the multi-metric
+multi_metric.AddMetric(ms_metric)
+
+# Test that we can get the number of metrics
+assert multi_metric.GetNumberOfMetrics() == 1
+
+# Set metric weights
+weights = itk.Array[itk.D](1)
+weights[0] = 0.5
+multi_metric.SetMetricWeights(weights)
+
+# Verify weights were set
+retrieved_weights = multi_metric.GetMetricWeights()
+assert retrieved_weights.GetSize() == 1
+
+print("Test passed!")