I've mostly seen multipart/x-mixed-replace used as a pre-video element solution for "streaming" jpeg to <img> element, a la mjpeg but the sub-resource of a multipart/x-mixed-replace can be of any type, and even switch between resoureces as far as I can tell.
This makes it impossible to sniff, which leads me to believe that we need to block multipart/x-mixed-replace entirely but I'm not at all sure of how web compatible this is.