diff --git a/cookbooks/aws-parallelcluster-computefleet/recipes/install/custom_parallelcluster_node.rb b/cookbooks/aws-parallelcluster-computefleet/recipes/install/custom_parallelcluster_node.rb
index 247823c173..788a715f33 100644
--- a/cookbooks/aws-parallelcluster-computefleet/recipes/install/custom_parallelcluster_node.rb
+++ b/cookbooks/aws-parallelcluster-computefleet/recipes/install/custom_parallelcluster_node.rb
@@ -19,9 +19,22 @@
 
 # TODO: once the pyenv Chef resource supports installing packages from a path (e.g. `pip install .`), convert the
 # bash block to a recipe that uses the pyenv resource.
-if aws_region.start_with?("us-iso") && platform?('amazon') && node['platform_version'] == "2"
+command = if aws_region.start_with?("us-iso")
+            "pip install . --no-build-isolation"
+          else
+            "pip install ."
+          end
+
+if aws_region.start_with?("us-iso")
+  dependency_package_name = "pypi-node-dependencies-#{node['cluster']['python-major-minor-version']}-#{node['kernel']['machine']}"
+  dependency_folder_name = dependency_package_name
+  if platform?('amazon') && node['platform_version'] == "2"
+    dependency_package_name = "node-dependencies"
+    dependency_folder_name = "node"
+  end
+
   remote_file "#{node['cluster']['base_dir']}/node-dependencies.tgz" do
-    source "#{node['cluster']['artifacts_s3_url']}/dependencies/PyPi/#{node['kernel']['machine']}/node-dependencies.tgz"
+    source "#{node['cluster']['artifacts_s3_url']}/dependencies/PyPi/#{node['kernel']['machine']}/#{dependency_package_name}.tgz"
     mode '0644'
     retries 3
     retry_delay 5
@@ -35,7 +48,7 @@
     code <<-REQ
       set -e
       tar xzf node-dependencies.tgz
-      cd node
+      cd #{dependency_folder_name}
       #{node_virtualenv_path}/bin/pip install * -f ./ --no-index
       REQ
   end
@@ -59,7 +72,7 @@
     mkdir aws-parallelcluster-custom-node
     tar -xzf aws-parallelcluster-node.tgz --directory aws-parallelcluster-custom-node
     cd aws-parallelcluster-custom-node/*aws-parallelcluster-node*
-    pip install .
+    #{command}
     deactivate
   NODE
 end
diff --git a/cookbooks/aws-parallelcluster-environment/recipes/install/cfn_bootstrap.rb b/cookbooks/aws-parallelcluster-environment/recipes/install/cfn_bootstrap.rb
index cfe95c4ed5..e795e70943 100644
--- a/cookbooks/aws-parallelcluster-environment/recipes/install/cfn_bootstrap.rb
+++ b/cookbooks/aws-parallelcluster-environment/recipes/install/cfn_bootstrap.rb
@@ -34,8 +34,14 @@
 end
 
 if aws_region.start_with?("us-iso")
+  dependency_package_name = "pypi-cfn-dependencies-#{node['cluster']['python-major-minor-version']}-#{node['kernel']['machine']}"
+  dependency_folder_name = dependency_package_name
+  if platform?('amazon') && node['platform_version'] == "2"
+    dependency_package_name = "cfn-dependencies"
+    dependency_folder_name = "cfn"
+  end
   remote_file "#{node['cluster']['base_dir']}/cfn-dependencies.tgz" do
-    source "#{node['cluster']['artifacts_s3_url']}/dependencies/PyPi/#{node['kernel']['machine']}/cfn-dependencies.tgz"
+    source "#{node['cluster']['artifacts_s3_url']}/dependencies/PyPi/#{node['kernel']['machine']}/#{dependency_package_name}.tgz"
     mode '0644'
     retries 3
     retry_delay 5
@@ -49,7 +55,7 @@
     code <<-REQ
       set -e
       tar xzf cfn-dependencies.tgz
-      cd cfn
+      cd #{dependency_folder_name}
       #{virtualenv_path}/bin/pip install * -f ./ --no-index
       REQ
   end
@@ -73,11 +79,16 @@
   retry_delay 5
 end
 
+command = if aws_region.start_with?("us-iso")
+            "#{virtualenv_path}/bin/pip install #{cfnbootstrap_package} --no-build-isolation"
+          else
+            "#{virtualenv_path}/bin/pip install #{cfnbootstrap_package}"
+          end
 bash "Install CloudFormation helpers from #{cfnbootstrap_package}" do
   user 'root'
   group 'root'
   cwd '/tmp'
-  code "#{virtualenv_path}/bin/pip install #{cfnbootstrap_package}"
+  code command
   creates "#{virtualenv_path}/bin/cfn-hup"
 end
 
diff --git a/cookbooks/aws-parallelcluster-environment/resources/efs/efs_redhat8.rb b/cookbooks/aws-parallelcluster-environment/resources/efs/efs_redhat8.rb
index b2ab45bc1b..abe333a933 100644
--- a/cookbooks/aws-parallelcluster-environment/resources/efs/efs_redhat8.rb
+++ b/cookbooks/aws-parallelcluster-environment/resources/efs/efs_redhat8.rb
@@ -21,3 +21,55 @@
 use 'partial/_redhat_based'
 use 'partial/_install_from_tar'
 use 'partial/_mount_umount'
+
+def adc_install_script_code(efs_utils_tarball, efs_utils_package, efs_utils_version)
+  <<-EFSUTILSINSTALL
+      set -e
+      tar xf #{efs_utils_tarball}
+      mv efs-proxy-dependencies-#{efs_utils_version}.tar.gz efs-utils-#{efs_utils_version}/src/proxy/
+      cd efs-utils-#{efs_utils_version}/src/proxy/
+      tar -xf efs-proxy-dependencies-#{efs_utils_version}.tar.gz
+      cargo build --offline
+      cd ../..
+      make rpm
+      yum -y install ./build/#{efs_utils_package}*rpm
+  EFSUTILSINSTALL
+end
+
+def prerequisites
+  %w(rpm-build make rust cargo openssl-devel)
+end
+
+action :install_efs_utils do
+  package_name = "amazon-efs-utils"
+  package_version = new_resource.efs_utils_version
+  efs_utils_tarball = "#{node['cluster']['sources_dir']}/efs-utils-#{package_version}.tar.gz"
+
+  if aws_region.start_with?("us-iso")
+
+    efs_proxy_deps = "efs-proxy-dependencies-#{package_version}.tar.gz"
+    efs_proxy_deps_tarball = "#{node['cluster']['sources_dir']}/#{efs_proxy_deps}"
+    efs_proxy_deps_url = "#{node['cluster']['artifacts_s3_url']}/dependencies/efs/#{efs_proxy_deps}"
+    remote_file efs_proxy_deps_tarball do
+      source efs_proxy_deps_url
+      mode '0644'
+      retries 3
+      retry_delay 5
+      action :create_if_missing
+    end
+
+    bash "install efs utils" do
+      cwd node['cluster']['sources_dir']
+      code adc_install_script_code(efs_utils_tarball, package_name, package_version)
+    end
+
+  else
+    # Install EFS Utils following https://docs.aws.amazon.com/efs/latest/ug/installing-amazon-efs-utils.html
+    bash "install efs utils" do
+      cwd node['cluster']['sources_dir']
+      code install_script_code(efs_utils_tarball, package_name, package_version)
+    end
+  end
+
+  action_increase_poll_interval
+end
diff --git a/cookbooks/aws-parallelcluster-environment/resources/efs/partial/_install_from_tar.rb b/cookbooks/aws-parallelcluster-environment/resources/efs/partial/_install_from_tar.rb
index cf65440cf0..c3e320c906 100644
--- a/cookbooks/aws-parallelcluster-environment/resources/efs/partial/_install_from_tar.rb
+++ b/cookbooks/aws-parallelcluster-environment/resources/efs/partial/_install_from_tar.rb
@@ -12,8 +12,13 @@
 # or in the "LICENSE.txt" file accompanying this file.
 # This file is distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, express or implied.
 # See the License for the specific language governing permissions and limitations under the License.
+package_name = "amazon-efs-utils"
 
 action :install_utils do
+  package_version = new_resource.efs_utils_version
+  efs_utils_tarball = "#{node['cluster']['sources_dir']}/efs-utils-#{package_version}.tar.gz"
+  efs_utils_url = "#{node['cluster']['artifacts_s3_url']}/dependencies/efs/v#{package_version}.tar.gz"
+
   package_repos 'update package repositories' do
     action :update
   end
@@ -29,11 +34,6 @@
 
   return if redhat_on_docker?
 
-  package_name = "amazon-efs-utils"
-  package_version = new_resource.efs_utils_version
-  efs_utils_tarball = "#{node['cluster']['sources_dir']}/efs-utils-#{package_version}.tar.gz"
-  efs_utils_url = "#{node['cluster']['artifacts_s3_url']}/dependencies/efs/v#{package_version}.tar.gz"
-
   # Do not install efs-utils if a same or newer version is already installed.
   return if already_installed?(package_name, package_version)
 
@@ -50,10 +50,22 @@
     action :create_if_missing
   end
 
+  action_install_efs_utils
+
   # Install EFS Utils following https://docs.aws.amazon.com/efs/latest/ug/installing-amazon-efs-utils.html
+  # bash "install efs utils" do
+  #   cwd node['cluster']['sources_dir']
+  #   code install_script_code(efs_utils_tarball, package_name, package_version)
+  # end
+  action_increase_poll_interval
+end
+
+action :install_efs_utils do
+  package_version = new_resource.efs_utils_version
+  efs_utils_tarball = "#{node['cluster']['sources_dir']}/efs-utils-#{package_version}.tar.gz"
+
   bash "install efs utils" do
     cwd node['cluster']['sources_dir']
     code install_script_code(efs_utils_tarball, package_name, package_version)
   end
-  action_increase_poll_interval
 end
diff --git a/cookbooks/aws-parallelcluster-platform/recipes/install/cookbook_virtualenv.rb b/cookbooks/aws-parallelcluster-platform/recipes/install/cookbook_virtualenv.rb
index cdc557df5f..8717b06a69 100644
--- a/cookbooks/aws-parallelcluster-platform/recipes/install/cookbook_virtualenv.rb
+++ b/cookbooks/aws-parallelcluster-platform/recipes/install/cookbook_virtualenv.rb
@@ -12,8 +12,10 @@
 # limitations under the License.
 
 virtualenv_path = cookbook_virtualenv_path
-pypi_s3_uri = "#{node['cluster']['artifacts_s3_url']}/dependencies/PyPi/pypi-dependencies-#{node['cluster']['python-major-minor-version']}-#{node['kernel']['machine']}.tgz"
+dependency_package_name = "pypi-cookbook-dependencies-#{node['cluster']['python-major-minor-version']}-#{node['kernel']['machine']}"
+pypi_s3_uri = "#{node['cluster']['artifacts_s3_url']}/dependencies/PyPi/#{dependency_package_name}.tgz"
 if platform?('amazon') && node['platform_version'] == "2"
+  dependency_package_name = "dependencies"
   pypi_s3_uri = "#{node['cluster']['artifacts_s3_url']}/dependencies/PyPi/#{node['kernel']['machine']}/cookbook-dependencies.tgz"
 end
 
@@ -31,22 +33,24 @@
   not_if { ::File.exist?("#{cookbook_virtualenv_path}/bin/activate") }
 end
 
-remote_file "#{node['cluster']['base_dir']}/cookbook-dependencies.tgz" do
-  source pypi_s3_uri
-  mode '0644'
-  retries 3
-  retry_delay 5
-  action :create_if_missing
-end
+if aws_region.start_with?("us-iso")
+  remote_file "#{node['cluster']['base_dir']}/cookbook-dependencies.tgz" do
+    source pypi_s3_uri
+    mode '0644'
+    retries 3
+    retry_delay 5
+    action :create_if_missing
+  end
 
-bash 'pip install' do
-  user 'root'
-  group 'root'
-  cwd "#{node['cluster']['base_dir']}"
-  code <<-REQ
+  bash 'pip install' do
+    user 'root'
+    group 'root'
+    cwd "#{node['cluster']['base_dir']}"
+    code <<-REQ
     set -e
     tar xzf cookbook-dependencies.tgz
-    cd dependencies
+    cd #{dependency_package_name}
     #{virtualenv_path}/bin/pip install * -f ./ --no-index
     REQ
+  end
 end
diff --git a/cookbooks/aws-parallelcluster-platform/spec/unit/recipes/cookbook_virtualenv_spec.rb b/cookbooks/aws-parallelcluster-platform/spec/unit/recipes/cookbook_virtualenv_spec.rb
index 65b83d509e..0ce79250cc 100644
--- a/cookbooks/aws-parallelcluster-platform/spec/unit/recipes/cookbook_virtualenv_spec.rb
+++ b/cookbooks/aws-parallelcluster-platform/spec/unit/recipes/cookbook_virtualenv_spec.rb
@@ -6,12 +6,15 @@
       cached(:python_version) { 'python_version' }
       cached(:system_pyenv_root) { 'system_pyenv_root' }
       cached(:virtualenv_path) { 'system_pyenv_root/versions/python_version/envs/cookbook_virtualenv' }
+      cached(:aws_region) { 'us-iso-test' }
 
       context "when cookbook virtualenv not installed yet" do
         cached(:chef_run) do
           runner = runner(platform: platform, version: version) do |node|
+            allow_any_instance_of(Object).to receive(:aws_region).and_return(aws_region)
             node.override['cluster']['system_pyenv_root'] = system_pyenv_root
             node.override['cluster']['python-version'] = python_version
+            node.override['cluster']['region'] = aws_region
           end
           runner.converge(described_recipe)
         end
@@ -32,13 +35,14 @@
           expect(node.default['cluster']['cookbook_virtualenv_path']).to eq(virtualenv_path)
           is_expected.to write_node_attributes('dump node attributes')
         end
-
-        it 'installs python packages' do
-          is_expected.to run_bash("pip install").with(
-            user: 'root',
-            group: 'root',
-            cwd: "#{node['cluster']['base_dir']}"
-          ).with_code(/tar xzf cookbook-dependencies.tgz/)
+        context "when in isolated region" do
+          it 'installs python packages' do
+            is_expected.to run_bash("pip install").with(
+              user: 'root',
+              group: 'root',
+              cwd: "#{node['cluster']['base_dir']}"
+            ).with_code(/tar xzf cookbook-dependencies.tgz/)
+          end
         end
       end
     end
diff --git a/util/upload-cookbook.sh b/util/upload-cookbook.sh
index c2169a4c3e..864ce56959 100755
--- a/util/upload-cookbook.sh
+++ b/util/upload-cookbook.sh
@@ -93,21 +93,22 @@ main() {
     # Create archive and md5
     _cwd=$(pwd)
     pushd "${_srcdir}" > /dev/null || exit
+    GIT_REF=$(git rev-parse HEAD)
     _stashName=$(git stash create)
-    git archive --format tar --prefix="aws-parallelcluster-cookbook-${_version}/" "${_stashName:-HEAD}" | gzip > "${_cwd}/aws-parallelcluster-cookbook-${_version}.tgz"
+    git archive --format tar --prefix="aws-parallelcluster-cookbook-${_version}/" "${_stashName:-HEAD}" | gzip > "${_cwd}/aws-parallelcluster-cookbook-${_version}-${GIT_REF}.tgz"
     #tar zcvf "${_cwd}/aws-parallelcluster-cookbook-${_version}.tgz" --transform "s,^aws-parallelcluster-cookbook/,aws-parallelcluster-cookbook-${_version}/," ../aws-parallelcluster-cookbook
     popd > /dev/null || exit
-    md5sum aws-parallelcluster-cookbook-${_version}.tgz > aws-parallelcluster-cookbook-${_version}.md5
+    md5sum aws-parallelcluster-cookbook-${_version}-${GIT_REF}.tgz > aws-parallelcluster-cookbook-${_version}-${GIT_REF}.md5
 
     # upload packages
     _key_path="parallelcluster/${_version}/cookbooks"
     if [ -n "${_scope}" ]; then
         _key_path="${_key_path}/${_scope}"
     fi
-    aws ${_profile} --region "${_region}" s3 cp aws-parallelcluster-cookbook-${_version}.tgz s3://${_bucket}/${_key_path}/aws-parallelcluster-cookbook-${_version}.tgz || _error_exit 'Failed to push cookbook to S3'
-    aws ${_profile} --region "${_region}" s3 cp aws-parallelcluster-cookbook-${_version}.md5 s3://${_bucket}/${_key_path}/aws-parallelcluster-cookbook-${_version}.md5 || _error_exit 'Failed to push cookbook md5 to S3'
-    aws ${_profile} --region "${_region}" s3api head-object --bucket ${_bucket} --key ${_key_path}/aws-parallelcluster-cookbook-${_version}.tgz --output text --query LastModified > aws-parallelcluster-cookbook-${_version}.tgz.date || _error_exit 'Failed to fetch LastModified date'
-    aws ${_profile} --region "${_region}" s3 cp aws-parallelcluster-cookbook-${_version}.tgz.date s3://${_bucket}/${_key_path}/aws-parallelcluster-cookbook-${_version}.tgz.date || _error_exit 'Failed to push cookbook date'
+    aws ${_profile} --region "${_region}" s3 cp aws-parallelcluster-cookbook-${_version}-${GIT_REF}.tgz s3://${_bucket}/${_key_path}/aws-parallelcluster-cookbook-${_version}-${GIT_REF}.tgz || _error_exit 'Failed to push cookbook to S3'
+    aws ${_profile} --region "${_region}" s3 cp aws-parallelcluster-cookbook-${_version}-${GIT_REF}.md5 s3://${_bucket}/${_key_path}/aws-parallelcluster-cookbook-${_version}-${GIT_REF}.md5 || _error_exit 'Failed to push cookbook md5 to S3'
+    aws ${_profile} --region "${_region}" s3api head-object --bucket ${_bucket} --key ${_key_path}/aws-parallelcluster-cookbook-${_version}.tgz --output text --query LastModified > aws-parallelcluster-cookbook-${_version}-${GIT_REF}.tgz.date || _error_exit 'Failed to fetch LastModified date'
+    aws ${_profile} --region "${_region}" s3 cp aws-parallelcluster-cookbook-${_version}-${GIT_REF}.tgz.date s3://${_bucket}/${_key_path}/aws-parallelcluster-cookbook-${_version}-${GIT_REF}.tgz.date || _error_exit 'Failed to push cookbook date'
 
     _bucket_region=$(aws ${_profile} s3api get-bucket-location --bucket ${_bucket} --output text)
     if [ ${_bucket_region} = "None" ]; then