diff --git a/Docs/sphinx_documentation/source/Basics.rst b/Docs/sphinx_documentation/source/Basics.rst
index fa08217c88a..90ef2869fae 100644
--- a/Docs/sphinx_documentation/source/Basics.rst
+++ b/Docs/sphinx_documentation/source/Basics.rst
@@ -668,6 +668,21 @@ entries in an inputs file:
    hydro.cfl = 0.9
    my_string = "A String"
 
+You can also remove the effect of having defined an input parameter at all using the
+``UNSET`` directive (parameters that are merely overridden will still be caught by
+:cpp:`pp.contains()` checks in code). Specifying ``keyword = 5`` in an input file and
+then ``UNSET = keyword`` subsequently in the input file or from the command line
+completely removes ``keyword`` from the ParmParse table. Multiple keywords can
+be removed simultaneously (``UNSET = key1 key2 key3``). if using the ``UNSET``
+directive with TOML-like input files, note that full parameter names must be used
+even if the UNSET falls within a TOML table:
+
+.. code-block:: none
+
+   [x]
+   a = 1  # Same as x.a = 1 at the root level
+
+   UNSET = x.a # full name required to remove x.a entry
 
 Setting Defaults via an Environment Variable
 --------------------------------------------
diff --git a/Src/Base/AMReX_ParmParse.H b/Src/Base/AMReX_ParmParse.H
index 99b03d962c3..64b765f3636 100644
--- a/Src/Base/AMReX_ParmParse.H
+++ b/Src/Base/AMReX_ParmParse.H
@@ -1773,6 +1773,9 @@ public:
     //! keyword for files to load
     static std::string const FileKeyword;
 
+    //! keyword for removing entries from the table
+    static std::string const UnsetKeyword;
+
     static std::string ParserPrefix;
 
     [[nodiscard]] std::string const& getPrefix () const;
diff --git a/Src/Base/AMReX_ParmParse.cpp b/Src/Base/AMReX_ParmParse.cpp
index d0d033c6713..b99c9348aef 100644
--- a/Src/Base/AMReX_ParmParse.cpp
+++ b/Src/Base/AMReX_ParmParse.cpp
@@ -40,6 +40,7 @@ namespace {
 }
 
 std::string const ParmParse::FileKeyword = "FILE";
+std::string const ParmParse::UnsetKeyword = "UNSET";
 std::string       ParmParse::ParserPrefix;
 
 ParmParse::ParmParse (std::string prefix, std::string parser_prefix)
@@ -772,6 +773,15 @@ addDefn (std::string& def, std::vector<std::string>& val,
         read_file(fname, tab);
         g_toml_table_key = std::move(prev_toml_table_key);
     }
+    //
+    // Check if this defn is an unset directive.
+    //
+    else if ( def == ParmParse::UnsetKeyword )
+    {
+        for (auto const& key : val) {
+            tab.erase(key);
+        }
+    }
     else
     {
         std::string key;
diff --git a/Tests/ParmParse/inputs b/Tests/ParmParse/inputs
index b578c3b0514..90eaaf6c876 100644
--- a/Tests/ParmParse/inputs
+++ b/Tests/ParmParse/inputs
@@ -156,3 +156,13 @@ macro.use_gpu.spacedim = 3
 #  endif
 
 #endif
+
+# UNSET directive tests
+unset_me = 123
+UNSET = unset_me
+
+unset_multi_a = 1
+unset_multi_b = 2
+UNSET = unset_multi_a unset_multi_b
+
+unset_kept = 77
diff --git a/Tests/ParmParse/main.cpp b/Tests/ParmParse/main.cpp
index e345a3eba1c..46015c4f446 100644
--- a/Tests/ParmParse/main.cpp
+++ b/Tests/ParmParse/main.cpp
@@ -335,6 +335,21 @@ int main(int argc, char* argv[])
         int n = pp.countname("string-for-testing-addfile");
         AMREX_ALWAYS_ASSERT(n==3 && s == "string for testing addfile");
     }
+    { // UNSET directive
+        ParmParse pp;
+        // "unset_me" is defined then immediately unset in the inputs file
+        int v = -1;
+        int found = pp.query("unset_me", v);
+        AMREX_ALWAYS_ASSERT(found == 0);
+        // "unset_multi_a" and "unset_multi_b" are unset together in inputs
+        found = pp.query("unset_multi_a", v);
+        AMREX_ALWAYS_ASSERT(found == 0);
+        found = pp.query("unset_multi_b", v);
+        AMREX_ALWAYS_ASSERT(found == 0);
+        // "unset_kept" is NOT unset, so it should still be present
+        pp.get("unset_kept", v);
+        AMREX_ALWAYS_ASSERT(v == 77);
+    }
     {
         amrex::Print() << "SUCCESS\n";
     }