diff --git a/cellxgene_schema_cli/cellxgene_schema/validate.py b/cellxgene_schema_cli/cellxgene_schema/validate.py
index 9bd6c475..041aecb7 100644
--- a/cellxgene_schema_cli/cellxgene_schema/validate.py
+++ b/cellxgene_schema_cli/cellxgene_schema/validate.py
@@ -1,5 +1,6 @@
 import logging
 import math
+import numbers
 import os
 import re
 from datetime import datetime
@@ -770,6 +771,7 @@ def _validate_uns_dict(self, uns_dict: dict) -> None:
                     self.errors.append(f"uns['{key}'] cannot be an empty value.")
             elif (
                 value is not None
+                and not isinstance(value, numbers.Number)
                 and type(value) is not bool
                 and not (isinstance(value, (np.bool_, np.bool)))
                 and len(value) == 0
diff --git a/cellxgene_schema_cli/tests/test_schema_compliance.py b/cellxgene_schema_cli/tests/test_schema_compliance.py
index d2050664..a918f728 100644
--- a/cellxgene_schema_cli/tests/test_schema_compliance.py
+++ b/cellxgene_schema_cli/tests/test_schema_compliance.py
@@ -1776,6 +1776,17 @@ def test_uns_scipy_matrices_cannot_be_empty(self, validator_with_adata):
         validator.validate_adata()
         assert validator.errors == ["ERROR: uns['test'] cannot be an empty value."]
 
+    def test_uns_numbers_are_allowed(self, validator_with_adata):
+        validator = validator_with_adata
+
+        validator.adata.uns["numpy.int64"] = numpy.int64(10)
+        validator.adata.uns["int"] = 1
+        validator.adata.uns["int_zero"] = 0
+        validator.adata.uns["float"] = float(4)
+        validator.adata.uns["numpy.float32"] = numpy.float32(3)
+        validator.validate_adata()
+        assert validator.errors == []
+
     def test_colors_happy_path_duplicates(self, validator_with_adata):
         validator = validator_with_adata
         validator.adata.uns["suspension_type_colors"] = numpy.array(["lightgrey", "lightgrey"])