diff --git a/lib/ruby_llm/providers/bedrock/models.rb b/lib/ruby_llm/providers/bedrock/models.rb
index c985f8f4..6d82d970 100644
--- a/lib/ruby_llm/providers/bedrock/models.rb
+++ b/lib/ruby_llm/providers/bedrock/models.rb
@@ -74,7 +74,17 @@ def model_id_with_region(model_id, model_data)
           return model_id unless model_data['inferenceTypesSupported']&.include?('INFERENCE_PROFILE')
           return model_id if model_data['inferenceTypesSupported']&.include?('ON_DEMAND')
 
-          "us.#{model_id}"
+          region_prefix = inference_profile_region_prefix
+          "#{region_prefix}.#{model_id}"
+        end
+
+        def inference_profile_region_prefix
+          # Extract region prefix from bedrock_region (e.g., "eu-west-3" -> "eu")
+          region = @config.bedrock_region.to_s
+          return 'us' if region.empty? # Default fallback
+          
+          # Take first two characters as the region prefix
+          region[0, 2]
         end
       end
     end
diff --git a/spec/ruby_llm/providers/bedrock/models_spec.rb b/spec/ruby_llm/providers/bedrock/models_spec.rb
index 961b52e4..0225bef3 100644
--- a/spec/ruby_llm/providers/bedrock/models_spec.rb
+++ b/spec/ruby_llm/providers/bedrock/models_spec.rb
@@ -101,4 +101,108 @@
       end
     end
   end
+
+  # New specs for region-aware inference profile handling
+  describe '#model_id_with_region with region awareness' do
+    let(:provider_instance) do
+      allow(RubyLLM.config).to receive(:bedrock_region).and_return('eu-west-3')
+      provider = RubyLLM::Providers::Bedrock.new(RubyLLM.config)
+      provider.extend(described_class)
+      provider
+    end
+
+    context 'with EU region configured' do
+      let(:inference_profile_model) do
+        {
+          'modelId' => 'anthropic.claude-3-7-sonnet-20250219-v1:0',
+          'inferenceTypesSupported' => ['INFERENCE_PROFILE']
+        }
+      end
+
+      let(:us_prefixed_model) do
+        {
+          'modelId' => 'us.anthropic.claude-opus-4-1-20250805-v1:0',
+          'inferenceTypesSupported' => ['INFERENCE_PROFILE']
+        }
+      end
+
+      it 'adds eu. prefix for inference profile models' do
+        result = provider_instance.send(:model_id_with_region, 
+                                      inference_profile_model['modelId'], 
+                                      inference_profile_model)
+        expect(result).to eq('eu.anthropic.claude-3-7-sonnet-20250219-v1:0')
+      end
+
+      it 'replaces us. prefix with eu. prefix' do
+        result = provider_instance.send(:model_id_with_region, 
+                                      us_prefixed_model['modelId'], 
+                                      us_prefixed_model)
+        expect(result).to eq('eu.anthropic.claude-opus-4-1-20250805-v1:0')
+      end
+    end
+
+    context 'with AP region configured' do
+      let(:provider_instance) do
+        allow(RubyLLM.config).to receive(:bedrock_region).and_return('ap-south-1')
+        provider = RubyLLM::Providers::Bedrock.new(RubyLLM.config)
+        provider.extend(described_class)
+        provider
+      end
+
+      it 'replaces existing region prefix with ap. prefix' do
+        model_data = {
+          'modelId' => 'us.anthropic.claude-opus-4-1-20250805-v1:0',
+          'inferenceTypesSupported' => ['INFERENCE_PROFILE']
+        }
+
+        result = provider_instance.send(:model_id_with_region, 
+                                      model_data['modelId'], 
+                                      model_data)
+        expect(result).to eq('ap.anthropic.claude-opus-4-1-20250805-v1:0')
+      end
+    end
+
+    context 'region prefix edge cases' do
+      it 'handles empty region gracefully' do
+        allow(RubyLLM.config).to receive(:bedrock_region).and_return('')
+        provider = RubyLLM::Providers::Bedrock.new(RubyLLM.config)
+        provider.extend(described_class)
+
+        model_data = {
+          'modelId' => 'anthropic.claude-opus-4-1-20250805-v1:0',
+          'inferenceTypesSupported' => ['INFERENCE_PROFILE']
+        }
+
+        result = provider.send(:model_id_with_region, 
+                              model_data['modelId'], 
+                              model_data)
+        expect(result).to eq('us.anthropic.claude-opus-4-1-20250805-v1:0')
+      end
+
+      it 'extracts region prefix from various AWS regions' do
+        regions_and_expected_prefixes = {
+          'eu-west-3' => 'eu',
+          'ap-south-1' => 'ap', 
+          'ca-central-1' => 'ca',
+          'sa-east-1' => 'sa'
+        }
+
+        regions_and_expected_prefixes.each do |region, expected_prefix|
+          allow(RubyLLM.config).to receive(:bedrock_region).and_return(region)
+          provider = RubyLLM::Providers::Bedrock.new(RubyLLM.config)
+          provider.extend(described_class)
+
+          model_data = {
+            'modelId' => 'anthropic.claude-opus-4-1-20250805-v1:0',
+            'inferenceTypesSupported' => ['INFERENCE_PROFILE']
+          }
+
+          result = provider.send(:model_id_with_region, 
+                                model_data['modelId'], 
+                                model_data)
+          expect(result).to eq("#{expected_prefix}.anthropic.claude-opus-4-1-20250805-v1:0")
+        end
+      end
+    end
+  end
 end