diff --git a/streams/buffer.ts b/streams/buffer.ts
index 5b93d6bb5213..5f4499b39419 100644
--- a/streams/buffer.ts
+++ b/streams/buffer.ts
@@ -232,3 +232,44 @@ export class LimitedTransformStream<T> extends TransformStream<T, T> {
     });
   }
 }
+
+/**
+ * A transform stream that only transforms from the zero-indexed `start` and `end` bytes (both inclusive).
+ *
+ * @example
+ * ```ts
+ * import { ByteSliceStream } from "https://deno.land/std@$STD_VERSION/streams/buffer.ts";
+ * const response = await fetch("https://example.com");
+ * const rangedStream = response.body!
+ *   .pipeThrough(new ByteSliceStream(3, 8));
+ * ```
+ */
+export class ByteSliceStream extends TransformStream<Uint8Array, Uint8Array> {
+  #offsetStart = 0;
+  #offsetEnd = 0;
+
+  constructor(start = 0, end = Infinity) {
+    super({
+      start: () => {
+        assert(start >= 0, "`start` must be greater than 0");
+        end += 1;
+      },
+      transform: (chunk, controller) => {
+        this.#offsetStart = this.#offsetEnd;
+        this.#offsetEnd += chunk.byteLength;
+        if (this.#offsetEnd > start) {
+          if (this.#offsetStart < start) {
+            chunk = chunk.slice(start - this.#offsetStart);
+          }
+          if (this.#offsetEnd >= end) {
+            chunk = chunk.slice(0, chunk.byteLength - this.#offsetEnd + end);
+            controller.enqueue(chunk);
+            controller.terminate();
+          } else {
+            controller.enqueue(chunk);
+          }
+        }
+      },
+    });
+  }
+}
diff --git a/streams/buffer_test.ts b/streams/buffer_test.ts
index 8e4295425606..22adf1523c17 100644
--- a/streams/buffer_test.ts
+++ b/streams/buffer_test.ts
@@ -1,8 +1,14 @@
 // Copyright 2018-2022 the Deno authors. All rights reserved. MIT license.
 
-import { assert, assertEquals, assertRejects } from "../testing/asserts.ts";
+import {
+  assert,
+  assertEquals,
+  assertRejects,
+  assertThrows,
+} from "../testing/asserts.ts";
 import {
   Buffer,
+  ByteSliceStream,
   LimitedBytesTransformStream,
   LimitedTransformStream,
 } from "./buffer.ts";
@@ -128,3 +134,79 @@ Deno.test("[streams] LimitedTransformStream error", async function () {
     }
   }, RangeError);
 });
+
+Deno.test("[streams] ByteSliceStream", async function () {
+  function createStream(start = 0, end = Infinity) {
+    return new ReadableStream({
+      start(controller) {
+        controller.enqueue(new Uint8Array([0, 1]));
+        controller.enqueue(new Uint8Array([2, 3]));
+        controller.close();
+      },
+    }).pipeThrough(new ByteSliceStream(start, end));
+  }
+
+  let chunks = [];
+
+  for await (const chunk of createStream(0, 3)) {
+    chunks.push(chunk);
+  }
+  assertEquals(chunks, [
+    new Uint8Array([0, 1]),
+    new Uint8Array([2, 3]),
+  ]);
+
+  chunks = [];
+  for await (const chunk of createStream(0, 1)) {
+    chunks.push(chunk);
+  }
+  assertEquals(chunks, [
+    new Uint8Array([0, 1]),
+  ]);
+
+  chunks = [];
+  for await (const chunk of createStream(0, 2)) {
+    chunks.push(chunk);
+  }
+  assertEquals(chunks, [
+    new Uint8Array([0, 1]),
+    new Uint8Array([2]),
+  ]);
+
+  chunks = [];
+  for await (const chunk of createStream(0, 3)) {
+    chunks.push(chunk);
+  }
+  assertEquals(chunks, [
+    new Uint8Array([0, 1]),
+    new Uint8Array([2, 3]),
+  ]);
+
+  chunks = [];
+  for await (const chunk of createStream(1, 3)) {
+    chunks.push(chunk);
+  }
+  assertEquals(chunks, [
+    new Uint8Array([1]),
+    new Uint8Array([2, 3]),
+  ]);
+
+  chunks = [];
+  for await (const chunk of createStream(2, 3)) {
+    chunks.push(chunk);
+  }
+  assertEquals(chunks, [
+    new Uint8Array([2, 3]),
+  ]);
+
+  chunks = [];
+  for await (const chunk of createStream(0, 10)) {
+    chunks.push(chunk);
+  }
+  assertEquals(chunks, [
+    new Uint8Array([0, 1]),
+    new Uint8Array([2, 3]),
+  ]);
+
+  assertThrows(() => createStream(-1, Infinity));
+});