Generate random sequence variants for directed-evolution libraries and robustness testing. These tools fill chosen positions with random residues drawn from configurable schemes, using standard nucleotide substitution rules for DNA and codon-based sampling for proteins. They provide a model-free baseline for exploring sequence space.
- Input: a starting sequence and the positions to vary (or a target mutation rate).
- Output: a library of randomized sequence variants drawn from the chosen substitution scheme.