diff --git a/app/lib/common/models/userdata/genotype_result.dart b/app/lib/common/models/userdata/genotype_result.dart
index 6f2ae8fd..aa90cb0c 100644
--- a/app/lib/common/models/userdata/genotype_result.dart
+++ b/app/lib/common/models/userdata/genotype_result.dart
@@ -63,9 +63,13 @@ class GenotypeResult implements Genotype {
 }
 
 extension FindGenotypeResultByKey on Map<String, GenotypeResult> {
+  bool isMissing(String genotypeKey) => this[genotypeKey] == null;
+
   GenotypeResult findOrMissing(String genotypeKey, BuildContext context) =>
-    this[genotypeKey] ?? GenotypeResult.missingResult(
-      GenotypeKey.extractGene(genotypeKey),
-      context,
-    );
-}
\ No newline at end of file
+    isMissing(genotypeKey)
+      ? GenotypeResult.missingResult(
+          GenotypeKey.extractGene(genotypeKey),
+          context,
+        )
+      : this[genotypeKey]!;
+}
diff --git a/app/lib/drug/widgets/annotation_cards/guideline.dart b/app/lib/drug/widgets/annotation_cards/guideline.dart
index 305bb0d9..1657da1d 100644
--- a/app/lib/drug/widgets/annotation_cards/guideline.dart
+++ b/app/lib/drug/widgets/annotation_cards/guideline.dart
@@ -136,14 +136,20 @@ class GuidelineAnnotationCard extends StatelessWidget {
 
   String _buildGuidelineTooltipText(BuildContext context) {
     final actualTooltip = drug.userGuideline != null
+      // Case 1: a guideline is present
       ? context.l10n.drugs_page_tooltip_guideline(
           drug.userGuideline!.externalData.first.source
         )
       : drug.userOrFirstGuideline != null
-        // Guideline for drug is present but not for genotype
-        ? context.l10n.drugs_page_tooltip_missing_guideline_for_drug_or_genotype(
+        // Case 2: a guideline for the drug is present but not for the genotype
+        ? drug.guidelineGenotypes.all(UserData.instance.genotypeResults!.isMissing)
+          // Case 2.1: all genes are not tested
+          ? context.l10n.drugs_page_tooltip_missing_guideline_not_tested
+          // Case 2.2: at least some genes tested
+          : context.l10n.drugs_page_tooltip_missing_guideline_for_drug_or_genotype(
             context.l10n.drugs_page_tooltip_missing_genotype
           )
+        // Case 3: the drug has no guidelines
         : context.l10n.drugs_page_tooltip_missing_guideline_for_drug_or_genotype(
             context.l10n.drugs_page_tooltip_missing_drug
           );
diff --git a/app/lib/l10n/app_en.arb b/app/lib/l10n/app_en.arb
index 3d53b695..5578f4f6 100644
--- a/app/lib/l10n/app_en.arb
+++ b/app/lib/l10n/app_en.arb
@@ -210,6 +210,7 @@
       }
     }
   },
+  "drugs_page_tooltip_missing_guideline_not_tested": "Guidelines provide recommendations on which drugs to use based on your DNA. However, your genetic test result does not include the information needed to make such a recommendation for this drug.",
 
   "drugs_page_tooltip_warfarin": "CPIC guidelines provide recommendations on which drugs to use based on your DNA. However, to calculate your warfarin dose, more information is needed.",
   "drugs_page_implication_warfarin": "More information is needed to calculate your warfarin dose.",