diff --git a/mlir/CMakeLists.txt b/mlir/CMakeLists.txt
index a888ac243b044..9e786154a2b40 100644
--- a/mlir/CMakeLists.txt
+++ b/mlir/CMakeLists.txt
@@ -174,6 +174,8 @@ configure_file(
 # disable all package setup and control it themselves.
 #-------------------------------------------------------------------------------
 
+set(MLIR_BINDINGS_PYTHON_NB_DOMAIN "mlir"
+  CACHE STRING "nanobind domain for MLIR python bindings.")
 set(MLIR_ENABLE_BINDINGS_PYTHON 0 CACHE BOOL
        "Enables building of Python bindings.")
 set(MLIR_DETECT_PYTHON_ENV_PRIME_SEARCH 1 CACHE BOOL
diff --git a/mlir/cmake/modules/AddMLIRPython.cmake b/mlir/cmake/modules/AddMLIRPython.cmake
index 0679db9cf93e1..815f65b106d94 100644
--- a/mlir/cmake/modules/AddMLIRPython.cmake
+++ b/mlir/cmake/modules/AddMLIRPython.cmake
@@ -667,7 +667,7 @@ function(add_mlir_python_extension libname extname)
     )
   elseif(ARG_PYTHON_BINDINGS_LIBRARY STREQUAL "nanobind")
     nanobind_add_module(${libname}
-      NB_DOMAIN mlir
+      NB_DOMAIN ${MLIR_BINDINGS_PYTHON_NB_DOMAIN}
       FREE_THREADED
       ${ARG_SOURCES}
     )