diff --git a/plugins/Kaleidoscope-Qukeys/README.md b/plugins/Kaleidoscope-Qukeys/README.md
index d146ae95c9..2369b60835 100644
--- a/plugins/Kaleidoscope-Qukeys/README.md
+++ b/plugins/Kaleidoscope-Qukeys/README.md
@@ -141,6 +141,39 @@ likely to generate errors and out-of-order events.
 >
 > Defaults to `75` (milliseconds).
 
+### `.setEnableOppositeHandsRule(enable)`
+
+> When set to `true`, qukeys will only resolve to their alternate (modifier)
+> value when the subsequent key press is on the opposite hand from the qukey.
+> Same-hand rollover will always produce the primary (tap) value, preventing
+> accidental modifier activation during normal typing. This implements the
+> "opposite hands rule" popularized by QMK's Achordion and Chordal Hold
+> features.
+>
+> Hand membership is determined by physical key position (column index), not by
+> the key's logical assignment. This means remapping keys via Chrysalis or
+> EEPROM does not affect the hand detection. On split keyboards like the
+> Keyboardio Model 01/100, keys with column index less than the split column
+> (default 8) are considered left-hand keys.
+>
+> Note that holding a qukey alone past the hold timeout will still activate the
+> alternate (modifier) value regardless of this setting. This is intentional, as
+> it allows using a modifier with a pointing device (e.g. `shift` + `click`).
+>
+> Defaults to `false` (disabled).
+
+### `.setSplitColumn(column)`
+
+> Sets the column index that divides left-hand keys from right-hand keys when
+> the opposite-hands rule is enabled. Keys with a column index less than this
+> value are considered left-hand keys; keys with a column index greater than or
+> equal to this value are considered right-hand keys.
+>
+> For the Keyboardio Model 01 and Model 100, the correct value is `8` (columns
+> 0-7 are the left hand, columns 8-15 are the right hand).
+>
+> Defaults to `8`.
+
 ### `.activate()`
 ### `.deactivate()`
 ### `.toggle()`
diff --git a/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.cpp b/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.cpp
index 0e256b0264..685d6721cc 100644
--- a/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.cpp
+++ b/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.cpp
@@ -194,6 +194,15 @@ bool Qukeys::processQueue() {
       // Otherwise, we've found a subsequent key press, so we record it for the
       // overlap comparison later, unless we've already done so.
       if (next_keypress_index == 0) {
+        // If the opposite-hands rule is enabled and this subsequent key is on
+        // the same hand as the qukey, immediately flush as primary. There's no
+        // need to wait for the overlap comparison because same-hand rollover
+        // is never treated as a modifier chord.
+        if (require_opposite_hands_ &&
+            !oppositeHands(queue_head_addr, event_queue_.addr(i))) {
+          flushEvent(queue_head_.primary_key);
+          return true;
+        }
         next_keypress_index = i;
       }
       continue;
@@ -218,6 +227,14 @@ bool Qukeys::processQueue() {
         flushEvent(event_key);
         return true;
       }
+      // If the opposite-hands rule is enabled, and the subsequent key is on
+      // the same hand as the qukey, skip the overlap delay and flush as
+      // primary immediately. Same-hand rollover is always treated as typing.
+      if (require_opposite_hands_ &&
+          !oppositeHands(queue_head_addr, event_queue_.addr(next_keypress_index))) {
+        flushEvent(queue_head_.primary_key);
+        return true;
+      }
       // Now we know the qukey has been released, but we need to check to see if
       // it's release should continue to be delayed during rollover -- if the
       // subsequent key is released soon enough after the qukey is released, it
@@ -246,6 +263,15 @@ bool Qukeys::processQueue() {
       // not a key press, there must be one in the queue, so it shouldn't be
       // necessary to confirm that `j` is a actually a key press.
       if (event_queue_.addr(j) == event_queue_.addr(i)) {
+        // If the opposite-hands rule is enabled, only allow the alternate
+        // (modifier) value when the subsequent key is on the opposite hand
+        // from the qukey. Same-hand rollover always produces the primary
+        // (tap) value.
+        if (require_opposite_hands_ &&
+            !oppositeHands(queue_head_addr, event_queue_.addr(i))) {
+          flushEvent(queue_head_.primary_key);
+          return true;
+        }
         // Next, verify that enough time has passed after the qukey was pressed
         // to make it eligible for its alternate value. This helps faster
         // typists avoid unintended modifiers in the output.
@@ -494,6 +520,13 @@ bool Qukeys::shouldWaitForTapRepeat() {
 
 // -----------------------------------------------------------------------------
 
+// Return true if the two key addresses are on opposite hands, based on the
+// configured split column. This is used by the opposite-hands rule to prevent
+// same-hand rollover from triggering modifiers.
+bool Qukeys::oppositeHands(KeyAddr a, KeyAddr b) const {
+  return (a.col() < split_column_) != (b.col() < split_column_);
+}
+
 // This function is here to provide the test for a SpaceCadet-type qukey, which
 // is any Qukey that has a modifier (including layer shifts) as its primary
 // value.
diff --git a/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.h b/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.h
index 29b5024197..4ab5a4a284 100644
--- a/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.h
+++ b/plugins/Kaleidoscope-Qukeys/src/kaleidoscope/plugin/Qukeys.h
@@ -141,6 +141,25 @@ class Qukeys : public kaleidoscope::Plugin {
     minimum_prior_interval_ = min_interval;
   }
 
+  // Enable or disable the opposite-hands rule for home row mods. When enabled,
+  // a qukey will only resolve to its alternate (modifier) value when the
+  // subsequent key is on the opposite hand. Same-hand rollover always produces
+  // the primary (tap) value, preventing accidental modifier activation during
+  // normal typing. The hand boundary is determined by column index: columns
+  // 0 through (split_column - 1) are the left hand, and columns split_column
+  // and above are the right hand.
+  void setEnableOppositeHandsRule(bool enable) {
+    require_opposite_hands_ = enable;
+  }
+
+  // Set the column index that divides left and right hands. Keys with column
+  // index less than this value are considered left-hand keys. Default is 8,
+  // which is correct for Keyboardio Model 01/100 (4x16 matrix, columns 0-7
+  // left, 8-15 right).
+  void setSplitColumn(uint8_t col) {
+    split_column_ = col;
+  }
+
   // Function for defining the array of qukeys data (in PROGMEM). It's a
   // template function that takes as its sole argument an array reference of
   // size `_qukeys_count`, so there's no need to use `sizeof` to calculate the
@@ -210,6 +229,13 @@ class Qukeys : public kaleidoscope::Plugin {
     Key alternate_key{Key_Transparent};
   } queue_head_;
 
+  // When true, qukeys will only resolve to their alternate value when the
+  // subsequent keypress is on the opposite hand.
+  bool require_opposite_hands_{false};
+
+  // The column index that divides left and right hands.
+  uint8_t split_column_{8};
+
   // Internal helper methods.
   bool processQueue();
   void flushEvent(Key event_key);
@@ -217,6 +243,7 @@ class Qukeys : public kaleidoscope::Plugin {
   bool isDualUseKey(Key key);
   bool releaseDelayed(uint16_t overlap_start, uint16_t overlap_end) const;
   bool isKeyAddrInQueueBeforeIndex(KeyAddr k, uint8_t index) const;
+  bool oppositeHands(KeyAddr a, KeyAddr b) const;
 
   // Tap-repeat feature support.
   struct {