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authoredFeb 20, 2025··
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‎docs/source/index.md

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@@ -30,20 +30,20 @@ compared to random background?*
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### Features added
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1) Now support FRAG format for single-cell ATAC-seq in `callpeak` and
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1) Now support FRAG format for **single-cell ATAC-seq** in `callpeak` and
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`pileup`. FRAG format is used by 10x Genomics to store alignments from
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the single-cell ATAC-seq pipeline `cellranger-atac` or the multi-omics
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pipeline `cellranger-arc`. The format is essentially BEDPE with two
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additional columns: the barcode and the count of fragments aligned to
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the same location with the same barcode. Support for FRAG in other
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tools is coming soon, as well as for `hmmratac` calls.
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If you specify FRAG as your input format:
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If you specify FRAG as your input format:
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- You can use a barcode list for a subset of cells with `--barcodes`,
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- You can use a barcode list for a subset of cells with `--barcodes`,
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then `callpeak` will identify peaks and `pileup` will build pileup
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track for the fragments of this subset of cells.
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- Duplicates will not get removed as we'll assume all fragments are
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- Duplicates will not get removed as we'll assume all fragments are
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valid. Optionally, an option, `--max-count`, can be applied to set
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the maximum count.
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@@ -63,7 +63,8 @@ before both steps. We implemented the `exclude` functions in both
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PETrackI and PETrackII to support this feature. For more detailed
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information and the reasoning behind it, refer to issue #680.
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4) We have tested Numpy>=2. Now MACS3 can be run on all Numpy >= 1.25.
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4) We have tested Numpy>=2. Now MACS3 can be run on Numpy version 1 and
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version 2.
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### Bug fixed
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