diff --git a/setup.py b/setup.py
index 6481f58f69070..f624766a9b0bd 100644
--- a/setup.py
+++ b/setup.py
@@ -784,6 +784,7 @@ def save_build_and_package_info(package_name, version_number, cuda_version, rocm
     download_url="https://github.com/microsoft/onnxruntime/tags",
     data_files=data_files,
     install_requires=install_requires,
+    python_requires=">=3.10",
     keywords="onnx machine learning",
     entry_points={
         "console_scripts": [