diff --git a/frontend/src/components/AppNodeBadge.vue b/frontend/src/components/AppNodeBadge.vue
index 449167e6..4f210f4e 100644
--- a/frontend/src/components/AppNodeBadge.vue
+++ b/frontend/src/components/AppNodeBadge.vue
@@ -18,10 +18,13 @@
           ? { breadcrumbs: [...currentBreadcrumbs, ...breadcrumbs] }
           : state || undefined
       "
-      v-html="name"
-    ></AppLink>
+    >
+      <AppNodeText :text="name" />
+    </AppLink>
     <span v-else>
-      <span class="name" v-html="name"></span>
+      <span class="name">
+        <AppNodeText :text="name" />
+      </span>
       <span v-if="info">({{ info }})</span>
     </span>
   </span>
@@ -31,6 +34,7 @@
 import { computed } from "vue";
 import { getCategoryIcon, getCategoryLabel } from "@/api/categories";
 import type { Node } from "@/api/model";
+import AppNodeText from "@/components/AppNodeText.vue";
 import { breadcrumbs as currentBreadcrumbs } from "@/global/breadcrumbs";
 import type { Breadcrumb } from "@/global/breadcrumbs";
 
diff --git a/frontend/src/components/AppNodeText.vue b/frontend/src/components/AppNodeText.vue
new file mode 100644
index 00000000..a5980315
--- /dev/null
+++ b/frontend/src/components/AppNodeText.vue
@@ -0,0 +1,228 @@
+<!--
+  The text of a node in the knowledge graph.
+
+  Selectively renders the following tags in HTML and SVG:
+    - <sup>
+    - <i>
+    - <a> with an `href` attribute surrounded in double quotes
+
+  There are two alternatives to the approach taken here, but neither are
+  sufficient.
+
+  1. We could use a sanitizer like [DOMPurify](https://github.com/cure53/DOMPurify)
+     to sanitize arbitrary strings, but that would strip out legitimate text
+     that an HTML parser might confuse for a tag. An example of such text can be
+     found here: <https://github.com/monarch-initiative/monarch-app/issues/887#issuecomment-2479676335>
+
+  2. We could escape the entire string, selectively unescape `&lt;sup&gt;` (and
+     so on), and then pass the string to `containerEl.innerHTML`. However, this
+     would lead to markup without the desired effect in SVG, since the <sup> and
+     <i> elements do not do anything in SVG.
+
+-->
+
+<template>
+  <tspan v-if="isSvg" ref="container">
+    {{ text }}
+  </tspan>
+  <span v-else ref="container">
+    {{ text }}
+  </span>
+</template>
+
+<script setup lang="ts">
+import { onMounted, onUpdated, ref } from "vue";
+
+type Props = {
+  text?: string;
+  isSvg?: boolean;
+};
+
+const props = withDefaults(defineProps<Props>(), {
+  text: "",
+  isSvg: false,
+});
+
+const container = ref<HTMLSpanElement | SVGTSpanElement | null>(null);
+
+type ReplacedTag = "sup" | "a" | "i";
+
+type Replacement = {
+  type: ReplacedTag;
+  start: [number, number];
+  end: [number, number];
+  startNode?: Text;
+  endNode?: Text;
+};
+
+type ReplacementPosition = {
+  type: "start" | "end";
+  replacement: Replacement;
+  at: [number, number];
+};
+
+const replacementTags = new Map([
+  [
+    "sup" as ReplacedTag,
+    {
+      regex: /(<sup>).*?(<\/sup>)/dg,
+      createSurroundingEl(isSvg: Boolean) {
+        return isSvg
+          ? document.createElementNS("http://www.w3.org/2000/svg", "tspan")
+          : document.createElement("sup");
+      },
+      afterMount(isSvg: Boolean, el: Element) {
+        if (!isSvg) return;
+        el.setAttribute("dy", "-1ex");
+        el.classList.add("svg-superscript");
+
+        // The next sibling will be the text node "</sup>". Check if there is
+        // remaining text after that. If there is, adjust the text baseline back
+        // down to the normal level.
+        const nextSibling = el.nextSibling!.nextSibling;
+        if (!nextSibling) return;
+
+        const range = new Range();
+        range.selectNode(nextSibling);
+
+        const tspan = document.createElementNS(
+          "http://www.w3.org/2000/svg",
+          "tspan",
+        );
+
+        tspan.setAttribute("dy", "+1ex");
+
+        range.surroundContents(tspan);
+      },
+    },
+  ],
+  [
+    "i" as ReplacedTag,
+    {
+      regex: /(<i>).*?(<\/i>)/dg,
+      createSurroundingEl(isSvg: Boolean) {
+        return isSvg
+          ? document.createElementNS("http://www.w3.org/2000/svg", "tspan")
+          : document.createElement("i");
+      },
+      afterMount(isSvg: Boolean, el: Element) {
+        if (!isSvg) return;
+        el.classList.add("svg-italic");
+      },
+    },
+  ],
+  [
+    "a" as ReplacedTag,
+    {
+      regex: /(<a href="http[^"]+">).*?(<\/a>)/dg,
+      createSurroundingEl(isSvg: Boolean) {
+        return isSvg
+          ? document.createElementNS("http://www.w3.org/2000/svg", "a")
+          : document.createElement("a");
+      },
+      afterMount(isSvg: Boolean, el: Element) {
+        // The previous sibling will be the text node containing the string
+        // <a href="http...">. Slice it to get the value of the href.
+        const tagTextNode = el.previousSibling!;
+        const href = tagTextNode.textContent!.slice(9, -2);
+        el.setAttribute("href", href);
+      },
+    },
+  ],
+]);
+
+function buildDOM(containerEl: Element) {
+  const text = props.text;
+
+  const containsOnlyText =
+    containerEl.childNodes.length === 1 &&
+    containerEl.firstChild?.nodeType === Node.TEXT_NODE &&
+    text !== null;
+
+  // This should always be false, but just in case-- bail out of the function
+  // if the element contains anything but a single text node.
+  if (!containsOnlyText) return;
+
+  const textNode = containerEl.firstChild as Text;
+
+  const replacements: Replacement[] = [];
+
+  // Create a list of every place there's a match for a start and end tag
+  // matched from the defined regexes.
+  Array.from(replacementTags.entries()).forEach(([type, { regex }]) => {
+    for (const match of text.matchAll(regex)) {
+      const { indices } = match;
+
+      replacements.push({
+        type,
+        start: indices![1],
+        end: indices![2],
+      });
+    }
+  });
+
+  // Now create a new list that has the position of each start and end token
+  const positions: ReplacementPosition[] = replacements.flatMap((x) => [
+    { type: "start", replacement: x, at: x.start },
+    { type: "end", replacement: x, at: x.end },
+  ]);
+
+  // Sort that list by the position of the tag token (with the last token
+  // first and the first token last).
+  //
+  // After that, iterate through each of the token positions and split the
+  // text node at the token's boundaries. Store the text node of each start
+  // and end tag in the `replacements` array to be used later.
+  positions
+    .sort((a, b) => {
+      return b.at[0] - a.at[0];
+    })
+    .forEach((position) => {
+      textNode.splitText(position.at[1]);
+      const node = textNode.splitText(position.at[0]);
+      position.replacement[`${position.type}Node`] = node;
+    });
+
+  // Build the correct DOM tree for each replacement found
+  replacements.forEach((replacement) => {
+    const { startNode, endNode, type } = replacement;
+    const { createSurroundingEl, afterMount } = replacementTags.get(type)!;
+
+    // Select the range that goes from the end of the opening tag text node to
+    // the start of the closing tag text node.
+    const range = new Range();
+    range.setStartAfter(startNode!);
+    range.setEndBefore(endNode!);
+
+    // Surround that range with the appropriate DOM element.
+    const el = createSurroundingEl(props.isSvg);
+    range.surroundContents(el);
+
+    // Run any code required after the container element is mounted.
+    afterMount(props.isSvg, el);
+
+    // Remove the start and end tag text nodes
+    startNode!.parentNode!.removeChild(startNode!);
+    endNode!.parentNode!.removeChild(endNode!);
+  });
+}
+
+onMounted(() => {
+  if (!container.value) return;
+  buildDOM(container.value);
+});
+
+onUpdated(() => {
+  if (!container.value) return;
+  buildDOM(container.value);
+});
+</script>
+
+<style>
+.svg-superscript {
+  font-size: 0.7rem;
+}
+.svg-italic {
+  font-style: italic;
+}
+</style>
diff --git a/frontend/src/pages/node/SectionOverview.vue b/frontend/src/pages/node/SectionOverview.vue
index 85e3e44c..fda894be 100644
--- a/frontend/src/pages/node/SectionOverview.vue
+++ b/frontend/src/pages/node/SectionOverview.vue
@@ -31,8 +31,9 @@
           v-tooltip="'Click to expand'"
           class="description truncate-10"
           tabindex="0"
-          v-html="node.description?.trim()"
-        ></p>
+        >
+          <AppNodeText :text="node.description?.trim()" />
+        </p>
       </AppDetail>
 
       <!-- inheritance -->
@@ -71,11 +72,9 @@
         title="Also Known As"
         :full="true"
       >
-        <p
-          class="truncate-2"
-          tabindex="0"
-          v-html="node.synonym?.join(',\n&nbsp;')"
-        ></p>
+        <p class="truncate-2" tabindex="0">
+          <AppNodeText :text="node.synonym?.join(',\n&nbsp;')" />
+        </p>
       </AppDetail>
 
       <!-- URI -->
@@ -155,6 +154,7 @@ import type { Node } from "@/api/model";
 import AppDetail from "@/components/AppDetail.vue";
 import AppDetails from "@/components/AppDetails.vue";
 import AppNodeBadge from "@/components/AppNodeBadge.vue";
+import AppNodeText from "@/components/AppNodeText.vue";
 import { scrollTo } from "@/router";
 import { sleep } from "@/util/debug";
 
diff --git a/frontend/src/pages/node/SectionTitle.vue b/frontend/src/pages/node/SectionTitle.vue
index 15dca5f3..0ee1c0f4 100644
--- a/frontend/src/pages/node/SectionTitle.vue
+++ b/frontend/src/pages/node/SectionTitle.vue
@@ -26,8 +26,8 @@
       >
         <span
           :style="{ textDecoration: node.deprecated ? 'line-through' : '' }"
-          v-html="node.name"
         >
+          <AppNodeText :text="node.name" />
         </span>
         <template v-if="node.deprecated"> (OBSOLETE)</template>
       </AppHeading>
@@ -48,6 +48,7 @@ import { computed } from "vue";
 import { truncate } from "lodash";
 import { getCategoryIcon, getCategoryLabel } from "@/api/categories";
 import type { Node } from "@/api/model";
+import AppNodeText from "@/components/AppNodeText.vue";
 import { parse } from "@/util/object";
 
 type Props = {