diff --git a/overrides/default.nix b/overrides/default.nix
index 2f776d1fe..4e0f03f2b 100644
--- a/overrides/default.nix
+++ b/overrides/default.nix
@@ -2958,6 +2958,9 @@ lib.composeManyExtensions [
           pkgs.xorg.libxshmfence
           pkgs.xorg.libxkbfile
         ];
+        postInstall = ''
+          rm -r $out/${final.python.sitePackages}/PySide6/__pycache__/
+        '';
       });
       pyside6 = prev.pyside6.overridePythonAttrs (_old: {
         # The PySide6/__init__.py script tries to find the Qt libraries
@@ -2972,6 +2975,7 @@ lib.composeManyExtensions [
         postFixup = ''
           ${pkgs.xorg.lndir}/bin/lndir ${final.pyside6-essentials}/${final.python.sitePackages}/PySide6 $out/${final.python.sitePackages}/PySide6
           ${pkgs.xorg.lndir}/bin/lndir ${final.pyside6-addons}/${final.python.sitePackages}/PySide6 $out/${final.python.sitePackages}/PySide6
+          rm -r $out/${final.python.sitePackages}/PySide6/__pycache__/
         '';
       });