diff --git a/.gitignore b/.gitignore
index aaa0f045e..be2ebb654 100644
--- a/.gitignore
+++ b/.gitignore
@@ -57,3 +57,7 @@ yarn.lock
 package-lock.json
 
 !test/fixtures/eval/node_modules
+
+# Generated files
+test/fixtures/ts/*js
+!test/fixtures/ts/transpile.cjs
diff --git a/docs/transports.md b/docs/transports.md
index 1ca3d21ee..a7a9757c5 100644
--- a/docs/transports.md
+++ b/docs/transports.md
@@ -236,6 +236,22 @@ logger.info('hello world')
 __NOTE: there is no "default" destination for a pipeline but
 a terminating target, i.e. a `Writable` stream.__
 
+### TypeScript compatibility
+
+Pino provides basic support for transports written in TypeScript.
+
+Ideally, they should be transpiled to ensure maximum compatibility, but some
+times you might want to use tools such as TS-Node, to execute your TypeScript
+code without having to go through an explicit transpilation step.
+
+You can use your TypeScript code without explicit transpilation, but there are
+some known caveats:
+- For "pure" TypeScript code, ES imports are still not supported (ES imports are
+  supported once the code is transpiled).
+- Only TS-Node is supported for now, there's no TSM support.
+- Running transports TypeScript code on TS-Node seems to be problematic on
+  Windows systems, there's no official support for that yet.
+
 ### Notable transports
 
 #### `pino/file`
diff --git a/lib/transport-stream.js b/lib/transport-stream.js
new file mode 100644
index 000000000..bbbf38aab
--- /dev/null
+++ b/lib/transport-stream.js
@@ -0,0 +1,47 @@
+'use strict'
+
+const { realImport, realRequire } = require('real-require')
+
+module.exports = loadTransportStreamBuilder
+
+/**
+ * Loads & returns a function to build transport streams
+ * @param {string} target
+ * @returns {function(object): Promise<import('stream').Writable>}
+ * @throws {Error} In case the target module does not export a function
+ */
+async function loadTransportStreamBuilder (target) {
+  let fn
+  try {
+    const toLoad = 'file://' + target
+
+    if (toLoad.endsWith('.ts') || toLoad.endsWith('.cts')) {
+      // TODO: add support for the TSM modules loader ( https://github.com/lukeed/tsm ).
+      if (process[Symbol.for('ts-node.register.instance')]) {
+        realRequire('ts-node/register')
+      } else if (process.env && process.env.TS_NODE_DEV) {
+        realRequire('ts-node-dev')
+      }
+      // TODO: Support ES imports once tsc, tap & ts-node provide better compatibility guarantees.
+      fn = realRequire(decodeURIComponent(target))
+    } else {
+      fn = (await realImport(toLoad))
+    }
+  } catch (error) {
+    // See this PR for details: https://github.com/pinojs/thread-stream/pull/34
+    if ((error.code === 'ENOTDIR' || error.code === 'ERR_MODULE_NOT_FOUND')) {
+      fn = realRequire(target)
+    } else {
+      throw error
+    }
+  }
+
+  // Depending on how the default export is performed, and on how the code is
+  // transpiled, we may find cases of two nested "default" objects.
+  // See https://github.com/pinojs/pino/issues/1243#issuecomment-982774762
+  if (typeof fn === 'object') fn = fn.default
+  if (typeof fn === 'object') fn = fn.default
+  if (typeof fn !== 'function') throw Error('exported worker is not a function')
+
+  return fn
+}
diff --git a/lib/worker-pipeline.js b/lib/worker-pipeline.js
index 32e7c0376..294fd0f3a 100644
--- a/lib/worker-pipeline.js
+++ b/lib/worker-pipeline.js
@@ -1,7 +1,7 @@
 'use strict'
 
 const EE = require('events')
-const { realImport, realRequire } = require('real-require')
+const loadTransportStreamBuilder = require('./transport-stream')
 const { pipeline, PassThrough } = require('stream')
 
 // This file is not checked by the code coverage tool,
@@ -11,18 +11,7 @@ const { pipeline, PassThrough } = require('stream')
 
 module.exports = async function ({ targets }) {
   const streams = await Promise.all(targets.map(async (t) => {
-    let fn
-    try {
-      const toLoad = 'file://' + t.target
-      fn = (await realImport(toLoad)).default
-    } catch (error) {
-      // See this PR for details: https://github.com/pinojs/thread-stream/pull/34
-      if ((error.code === 'ENOTDIR' || error.code === 'ERR_MODULE_NOT_FOUND')) {
-        fn = realRequire(t.target)
-      } else {
-        throw error
-      }
-    }
+    const fn = await loadTransportStreamBuilder(t.target)
     const stream = await fn(t.options)
     return stream
   }))
diff --git a/lib/worker.js b/lib/worker.js
index 917bffe27..38c37d817 100644
--- a/lib/worker.js
+++ b/lib/worker.js
@@ -2,7 +2,7 @@
 
 const pino = require('../pino.js')
 const build = require('pino-abstract-transport')
-const { realImport, realRequire } = require('real-require')
+const loadTransportStreamBuilder = require('./transport-stream')
 
 // This file is not checked by the code coverage tool,
 // as it is not reliable.
@@ -11,18 +11,7 @@ const { realImport, realRequire } = require('real-require')
 
 module.exports = async function ({ targets, levels }) {
   targets = await Promise.all(targets.map(async (t) => {
-    let fn
-    try {
-      const toLoad = 'file://' + t.target
-      fn = (await realImport(toLoad)).default
-    } catch (error) {
-      // See this PR for details: https://github.com/pinojs/thread-stream/pull/34
-      if ((error.code === 'ENOTDIR' || error.code === 'ERR_MODULE_NOT_FOUND')) {
-        fn = realRequire(t.target)
-      } else {
-        throw error
-      }
-    }
+    const fn = await loadTransportStreamBuilder(t.target)
     const stream = await fn(t.options)
     return {
       level: t.level,
diff --git a/package.json b/package.json
index cc2da66a9..0f9e94cb1 100644
--- a/package.json
+++ b/package.json
@@ -23,12 +23,13 @@
     "docs": "docsify serve",
     "browser-test": "airtap --local 8080 test/browser*test.js",
     "lint": "eslint .",
-    "test": "npm run lint && tap && jest test/jest && npm run test-types",
-    "test-ci": "npm run lint && tap --no-check-coverage --coverage-report=lcovonly && npm run test-types",
-    "test-ci-pnpm": "pnpm run lint && tap --no-coverage --no-check-coverage && pnpm run test-types",
-    "test-ci-yarn-pnp": "yarn run lint && tap --no-check-coverage --coverage-report=lcovonly",
+    "test": "npm run lint && npm run transpile && tap --ts && jest test/jest && npm run test-types",
+    "test-ci": "npm run lint && npm run transpile && tap --ts --no-check-coverage --coverage-report=lcovonly && npm run test-types",
+    "test-ci-pnpm": "pnpm run lint && npm run transpile && tap --ts --no-coverage --no-check-coverage && pnpm run test-types",
+    "test-ci-yarn-pnp": "yarn run lint && npm run transpile && tap --ts --no-check-coverage --coverage-report=lcovonly",
     "test-types": "tsc && tsd && ts-node test/types/pino.ts",
-    "cov-ui": "tap --coverage-report=html",
+    "transpile": "node ./test/fixtures/ts/transpile.cjs",
+    "cov-ui": "tap --ts --coverage-report=html",
     "bench": "node benchmarks/utils/runbench all",
     "bench-basic": "node benchmarks/utils/runbench basic",
     "bench-object": "node benchmarks/utils/runbench object",
@@ -67,7 +68,9 @@
   },
   "homepage": "http://getpino.io",
   "devDependencies": {
+    "@types/flush-write-stream": "^1.0.0",
     "@types/node": "^17.0.0",
+    "@types/tap": "^15.0.6",
     "airtap": "4.0.4",
     "benchmark": "^2.1.4",
     "bole": "^4.0.0",
@@ -97,7 +100,7 @@
     "tap": "^16.0.0",
     "tape": "^5.0.0",
     "through2": "^4.0.0",
-    "ts-node": "^10.3.0",
+    "ts-node": "^10.7.0",
     "tsd": "^0.20.0",
     "typescript": "^4.4.4",
     "winston": "^3.3.3"
diff --git a/test/fixtures/transport-wrong-export-type.js b/test/fixtures/transport-wrong-export-type.js
new file mode 100644
index 000000000..ed0affd58
--- /dev/null
+++ b/test/fixtures/transport-wrong-export-type.js
@@ -0,0 +1,3 @@
+module.exports = {
+  completelyUnrelatedProperty: 'Just a very incorrect transport worker implementation'
+}
diff --git a/test/fixtures/ts/to-file-transport-with-transform.ts b/test/fixtures/ts/to-file-transport-with-transform.ts
new file mode 100644
index 000000000..e3586a02d
--- /dev/null
+++ b/test/fixtures/ts/to-file-transport-with-transform.ts
@@ -0,0 +1,18 @@
+import * as fs from 'fs'
+import { once } from 'events'
+import { Transform } from 'stream'
+
+async function run (opts: {  destination?: fs.PathLike }): Promise<Transform> {
+  if (!opts.destination) throw new Error('kaboom')
+  const stream = fs.createWriteStream(opts.destination)
+  await once(stream, 'open')
+  const t = new Transform({
+    transform (chunk, enc, cb) {
+      setImmediate(cb, null, chunk.toString().toUpperCase())
+    }
+  })
+  t.pipe(stream)
+  return t
+}
+
+export default run
diff --git a/test/fixtures/ts/to-file-transport.ts b/test/fixtures/ts/to-file-transport.ts
new file mode 100644
index 000000000..6ebf09c75
--- /dev/null
+++ b/test/fixtures/ts/to-file-transport.ts
@@ -0,0 +1,11 @@
+import * as fs from 'fs'
+import { once } from 'events'
+
+async function run (opts: { destination?: fs.PathLike }): Promise<fs.WriteStream> {
+  if (!opts.destination) throw new Error('kaboom')
+  const stream = fs.createWriteStream(opts.destination, { encoding: 'utf8' })
+  await once(stream, 'open')
+  return stream
+}
+
+export default run
diff --git a/test/fixtures/ts/transpile.cjs b/test/fixtures/ts/transpile.cjs
new file mode 100755
index 000000000..2b0ddf142
--- /dev/null
+++ b/test/fixtures/ts/transpile.cjs
@@ -0,0 +1,40 @@
+#!/usr/bin/env node
+
+const execa = require('execa')
+const fs = require('fs')
+
+const existsSync = fs.existsSync
+const stat = fs.promises.stat
+
+// Hardcoded parameters
+const esVersions = ['es5', 'es6', 'es2017', 'esnext']
+const filesToTranspile = ['to-file-transport.ts']
+
+async function transpile () {
+  process.chdir(__dirname)
+
+  const runner = (process.env.npm_config_user_agent || '').match(/yarn/)
+    ? 'yarn'
+    : 'npx'
+
+  for (const sourceFileName of filesToTranspile) {
+    const sourceStat = await stat(sourceFileName)
+
+    for (const esVersion of esVersions) {
+      const intermediateFileName = sourceFileName.replace(/\.ts$/, '.js')
+      const targetFileName = sourceFileName.replace(/\.ts$/, `.${esVersion}.cjs`)
+
+      const shouldTranspile = !existsSync(targetFileName) || (await stat(targetFileName)).mtimeMs < sourceStat.mtimeMs
+
+      if (shouldTranspile) {
+        await execa(runner, ['tsc', '--target', esVersion, '--module', 'commonjs', sourceFileName])
+        await execa('mv', [intermediateFileName, targetFileName])
+      }
+    }
+  }
+}
+
+transpile().catch(err => {
+  process.exitCode = 1
+  throw err
+})
diff --git a/test/fixtures/ts/transport-exit-immediately-with-async-dest.ts b/test/fixtures/ts/transport-exit-immediately-with-async-dest.ts
new file mode 100644
index 000000000..288f0bf98
--- /dev/null
+++ b/test/fixtures/ts/transport-exit-immediately-with-async-dest.ts
@@ -0,0 +1,15 @@
+import pino from '../../..'
+import { join } from 'path'
+
+const transport = pino.transport({
+  target: join(__dirname, 'to-file-transport-with-transform.ts'),
+  options: {
+    destination: process.argv[2]
+  }
+})
+const logger = pino(transport)
+
+logger.info('Hello')
+logger.info('World')
+
+process.exit(0)
diff --git a/test/fixtures/ts/transport-exit-immediately.ts b/test/fixtures/ts/transport-exit-immediately.ts
new file mode 100644
index 000000000..21f2ab703
--- /dev/null
+++ b/test/fixtures/ts/transport-exit-immediately.ts
@@ -0,0 +1,10 @@
+import pino from '../../..'
+
+const transport = pino.transport({
+  target: 'pino/file'
+})
+const logger = pino(transport)
+
+logger.info('Hello')
+
+process.exit(0)
diff --git a/test/fixtures/ts/transport-exit-on-ready.ts b/test/fixtures/ts/transport-exit-on-ready.ts
new file mode 100644
index 000000000..a1f6a842b
--- /dev/null
+++ b/test/fixtures/ts/transport-exit-on-ready.ts
@@ -0,0 +1,11 @@
+import pino from '../../..'
+
+const transport = pino.transport({
+  target: 'pino/file'
+})
+const logger = pino(transport)
+
+transport.on('ready', function () {
+  logger.info('Hello')
+  process.exit(0)
+})
diff --git a/test/fixtures/ts/transport-main.ts b/test/fixtures/ts/transport-main.ts
new file mode 100644
index 000000000..fdf991445
--- /dev/null
+++ b/test/fixtures/ts/transport-main.ts
@@ -0,0 +1,8 @@
+import { join } from 'path'
+import pino from '../../..'
+
+const transport = pino.transport({
+  target: join(__dirname, 'transport-worker.ts')
+})
+const logger = pino(transport)
+logger.info('Hello')
diff --git a/test/fixtures/ts/transport-string-stdout.ts b/test/fixtures/ts/transport-string-stdout.ts
new file mode 100644
index 000000000..0c9cfa7d7
--- /dev/null
+++ b/test/fixtures/ts/transport-string-stdout.ts
@@ -0,0 +1,8 @@
+import pino from '../../..'
+
+const transport = pino.transport({
+  target: 'pino/file',
+  options: { destination: '1' }
+})
+const logger = pino(transport)
+logger.info('Hello')
diff --git a/test/fixtures/ts/transport-worker.ts b/test/fixtures/ts/transport-worker.ts
new file mode 100644
index 000000000..7af63da38
--- /dev/null
+++ b/test/fixtures/ts/transport-worker.ts
@@ -0,0 +1,14 @@
+import { Writable } from 'stream'
+
+export default (): Writable => {
+  const myTransportStream = new Writable({
+    autoDestroy: true,
+    write (chunk, _enc, cb) {
+      console.log(chunk.toString())
+      cb()
+    },
+    defaultEncoding: 'utf8'
+  })
+
+  return myTransportStream
+}
diff --git a/test/helper.d.ts b/test/helper.d.ts
new file mode 100644
index 000000000..cc10db1f0
--- /dev/null
+++ b/test/helper.d.ts
@@ -0,0 +1,4 @@
+import { PathLike } from 'fs'
+
+export declare function watchFileCreated(filename: PathLike): Promise<void>
+export declare function watchForWrite(filename: PathLike, testString: string): Promise<void>
diff --git a/test/transport/big.test.js b/test/transport/big.test.js
index aac2a24ec..b132fc6dc 100644
--- a/test/transport/big.test.js
+++ b/test/transport/big.test.js
@@ -2,7 +2,6 @@
 
 const { test } = require('tap')
 const { join } = require('path')
-const { once } = require('events')
 const { createReadStream } = require('fs')
 const { promisify } = require('util')
 const execa = require('execa')
@@ -16,10 +15,17 @@ const sleep = promisify(setTimeout)
 
 test('eight million lines', async ({ equal, comment }) => {
   const destination = file()
-  const child = execa(process.argv[0], [join(__dirname, '..', 'fixtures', 'transport-many-lines.js'), destination])
+  await execa(process.argv[0], [join(__dirname, '..', 'fixtures', 'transport-many-lines.js'), destination])
+
+  if (process.platform !== 'win32') {
+    try {
+      await execa('sync') // Wait for the file to be writen to disk
+    } catch {
+      // Just a fallback, this should be unreachable
+    }
+  }
+  await sleep(1000) // It seems that sync is not enough (even in POSIX systems)
 
-  await once(child, 'exit')
-  await sleep(1000) // wait for the file to be written
   const toWrite = 8 * 1000000
   let count = 0
   await pipeline(createReadStream(destination), split(), new Writable({
diff --git a/test/transport/core.test.js b/test/transport/core.test.js
index c53eac423..5b3f4297f 100644
--- a/test/transport/core.test.js
+++ b/test/transport/core.test.js
@@ -80,6 +80,32 @@ test('pino.transport errors if file does not exists', ({ plan, pass }) => {
   })
 })
 
+test('pino.transport errors if transport worker module does not export a function', ({ plan, equal }) => {
+  // TODO: add case for non-pipelined single target (needs changes in thread-stream)
+  plan(2)
+  const manyTargetsInstance = pino.transport({
+    targets: [{
+      level: 'info',
+      target: join(__dirname, '..', 'fixtures', 'transport-wrong-export-type.js')
+    }, {
+      level: 'info',
+      target: join(__dirname, '..', 'fixtures', 'transport-wrong-export-type.js')
+    }]
+  })
+  manyTargetsInstance.on('error', function (e) {
+    equal(e.message, 'exported worker is not a function')
+  })
+
+  const pipelinedInstance = pino.transport({
+    pipeline: [{
+      target: join(__dirname, '..', 'fixtures', 'transport-wrong-export-type.js')
+    }]
+  })
+  pipelinedInstance.on('error', function (e) {
+    equal(e.message, 'exported worker is not a function')
+  })
+})
+
 test('pino.transport with esm', async ({ same, teardown }) => {
   const destination = file()
   const transport = pino.transport({
diff --git a/test/transport/core.test.ts b/test/transport/core.test.ts
new file mode 100644
index 000000000..a1c80d847
--- /dev/null
+++ b/test/transport/core.test.ts
@@ -0,0 +1,236 @@
+import * as os from 'os'
+import { join } from 'path'
+import { once } from 'events'
+import fs from 'fs'
+import { watchFileCreated } from '../helper'
+import { test } from 'tap'
+import pino from '../../'
+import * as url from 'url'
+import { default as strip } from 'strip-ansi'
+import execa from 'execa'
+import writer from 'flush-write-stream'
+
+if (process.platform === 'win32') {
+  // TODO: Implement .ts files loading support for Windows
+  process.exit()
+}
+
+const readFile = fs.promises.readFile
+const { pid } = process
+const hostname = os.hostname()
+
+test('pino.transport with file', async ({ same, teardown }) => {
+  const destination = join(
+    os.tmpdir(),
+    '_' + Math.random().toString(36).substr(2, 9)
+  )
+  const transport = pino.transport({
+    target: join(__dirname, '..', 'fixtures', 'ts', 'to-file-transport.ts'),
+    options: { destination }
+  })
+  teardown(transport.end.bind(transport))
+  const instance = pino(transport)
+  instance.info('hello')
+  await watchFileCreated(destination)
+  const result = JSON.parse(await readFile(destination, { encoding: 'utf8' }))
+  delete result.time
+  same(result, {
+    pid,
+    hostname,
+    level: 30,
+    msg: 'hello'
+  })
+})
+
+test('pino.transport with file (no options + error handling)', async ({ equal }) => {
+  const transport = pino.transport({
+    target: join(__dirname, '..', 'fixtures', 'ts', 'to-file-transport.ts')
+  })
+  const [err] = await once(transport, 'error')
+  equal(err.message, 'kaboom')
+})
+
+test('pino.transport with file URL', async ({ same, teardown }) => {
+  const destination = join(
+    os.tmpdir(),
+    '_' + Math.random().toString(36).substr(2, 9)
+  )
+  const transport = pino.transport({
+    target: url.pathToFileURL(join(__dirname, '..', 'fixtures', 'ts', 'to-file-transport.ts')).href,
+    options: { destination }
+  })
+  teardown(transport.end.bind(transport))
+  const instance = pino(transport)
+  instance.info('hello')
+  await watchFileCreated(destination)
+  const result = JSON.parse(await readFile(destination, { encoding: 'utf8' }))
+  delete result.time
+  same(result, {
+    pid,
+    hostname,
+    level: 30,
+    msg: 'hello'
+  })
+})
+
+test('pino.transport with two files', async ({ same, teardown }) => {
+  const dest1 = join(
+    os.tmpdir(),
+    '_' + Math.random().toString(36).substr(2, 9)
+  )
+  const dest2 = join(
+    os.tmpdir(),
+    '_' + Math.random().toString(36).substr(2, 9)
+  )
+  const transport = pino.transport({
+    targets: [{
+      level: 'info',
+      target: join(__dirname, '..', 'fixtures', 'ts', 'to-file-transport.ts'),
+      options: { destination: dest1 }
+    }, {
+      level: 'info',
+      target: join(__dirname, '..', 'fixtures', 'ts', 'to-file-transport.ts'),
+      options: { destination: dest2 }
+    }]
+  })
+
+  teardown(transport.end.bind(transport))
+
+  const instance = pino(transport)
+  instance.info('hello')
+
+  await Promise.all([watchFileCreated(dest1), watchFileCreated(dest2)])
+
+  const result1 = JSON.parse(await readFile(dest1, { encoding: 'utf8' }))
+  delete result1.time
+  same(result1, {
+    pid,
+    hostname,
+    level: 30,
+    msg: 'hello'
+  })
+  const result2 = JSON.parse(await readFile(dest2, { encoding: 'utf8' }))
+  delete result2.time
+  same(result2, {
+    pid,
+    hostname,
+    level: 30,
+    msg: 'hello'
+  })
+})
+
+test('no transport.end()', async ({ same, teardown }) => {
+  const destination = join(
+    os.tmpdir(),
+    '_' + Math.random().toString(36).substr(2, 9)
+  )
+  const transport = pino.transport({
+    target: join(__dirname, '..', 'fixtures', 'ts', 'to-file-transport.ts'),
+    options: { destination }
+  })
+  const instance = pino(transport)
+  instance.info('hello')
+  await watchFileCreated(destination)
+  const result = JSON.parse(await readFile(destination, { encoding: 'utf8' }))
+  delete result.time
+  same(result, {
+    pid,
+    hostname,
+    level: 30,
+    msg: 'hello'
+  })
+})
+
+test('autoEnd = false', async ({ equal, same, teardown }) => {
+  const destination = join(
+    os.tmpdir(),
+    '_' + Math.random().toString(36).substr(2, 9)
+  )
+  const count = process.listenerCount('exit')
+  const transport = pino.transport({
+    target: join(__dirname, '..', 'fixtures', 'ts', 'to-file-transport.ts'),
+    options: { destination },
+    worker: { autoEnd: false }
+  })
+  teardown(transport.end.bind(transport))
+  await once(transport, 'ready')
+
+  const instance = pino(transport)
+  instance.info('hello')
+
+  await watchFileCreated(destination)
+
+  equal(count, process.listenerCount('exit'))
+
+  const result = JSON.parse(await readFile(destination, { encoding: 'utf8' }))
+  delete result.time
+  same(result, {
+    pid,
+    hostname,
+    level: 30,
+    msg: 'hello'
+  })
+})
+
+test('stdout in worker', async ({ not }) => {
+  let actual = ''
+  const child = execa(process.argv[0], ['-r', 'ts-node/register', join(__dirname, '..', 'fixtures', 'ts', 'transport-main.ts')])
+
+  child.stdout?.pipe(writer((s, enc, cb) => {
+    actual += s
+    cb()
+  }))
+  await once(child, 'close')
+  not(strip(actual).match(/Hello/), null)
+})
+
+test('log and exit on ready', async ({ not }) => {
+  let actual = ''
+  const child = execa(process.argv[0], ['-r', 'ts-node/register', join(__dirname, '..', 'fixtures', 'ts', 'transport-exit-on-ready.ts')])
+
+  child.stdout?.pipe(writer((s, enc, cb) => {
+    actual += s
+    cb()
+  }))
+  await once(child, 'close')
+  not(strip(actual).match(/Hello/), null)
+})
+
+test('log and exit before ready', async ({ not }) => {
+  let actual = ''
+  const child = execa(process.argv[0], ['-r', 'ts-node/register', join(__dirname, '..', 'fixtures', 'ts', 'transport-exit-immediately.ts')])
+
+  child.stdout?.pipe(writer((s, enc, cb) => {
+    actual += s
+    cb()
+  }))
+  await once(child, 'close')
+  not(strip(actual).match(/Hello/), null)
+})
+
+test('log and exit before ready with async dest', async ({ not }) => {
+  const destination = join(
+    os.tmpdir(),
+    '_' + Math.random().toString(36).substr(2, 9)
+  )
+  const child = execa(process.argv[0], ['-r', 'ts-node/register', join(__dirname, '..', 'fixtures', 'ts', 'transport-exit-immediately-with-async-dest.ts'), destination])
+
+  await once(child, 'exit')
+
+  const actual = await readFile(destination, { encoding: 'utf8' })
+
+  not(strip(actual).match(/HELLO/), null)
+  not(strip(actual).match(/WORLD/), null)
+})
+
+test('string integer destination', async ({ not }) => {
+  let actual = ''
+  const child = execa(process.argv[0], ['-r', 'ts-node/register', join(__dirname, '..', 'fixtures', 'ts', 'transport-string-stdout.ts')])
+
+  child.stdout?.pipe(writer((s, enc, cb) => {
+    actual += s
+    cb()
+  }))
+  await once(child, 'close')
+  not(strip(actual).match(/Hello/), null)
+})
diff --git a/test/transport/core.transpiled.test.ts b/test/transport/core.transpiled.test.ts
new file mode 100644
index 000000000..614c25887
--- /dev/null
+++ b/test/transport/core.transpiled.test.ts
@@ -0,0 +1,116 @@
+import * as os from 'os'
+import { join } from 'path'
+import { once } from 'events'
+import fs from 'fs'
+import { watchFileCreated } from '../helper'
+import { test } from 'tap'
+import pino from '../../'
+import * as url from 'url'
+import { default as strip } from 'strip-ansi'
+import execa from 'execa'
+import writer from 'flush-write-stream'
+
+const readFile = fs.promises.readFile
+
+const { pid } = process
+const hostname = os.hostname()
+
+// A subset of the test from core.test.js, we don't need all of them to check for compatibility
+function runTests(esVersion: string): void {
+  test(`(ts -> ${esVersion}) pino.transport with file`, async ({ same, teardown }) => {
+    const destination = join(
+      os.tmpdir(),
+      '_' + Math.random().toString(36).substr(2, 9)
+    )
+    const transport = pino.transport({
+      target: join(__dirname, '..', 'fixtures', 'ts', `to-file-transport.${esVersion}.cjs`),
+      options: { destination }
+    })
+    teardown(transport.end.bind(transport))
+    const instance = pino(transport)
+    instance.info('hello')
+    await watchFileCreated(destination)
+    const result = JSON.parse(await readFile(destination, { encoding: 'utf8' }))
+    delete result.time
+    same(result, {
+      pid,
+      hostname,
+      level: 30,
+      msg: 'hello'
+    })
+  })
+
+  test(`(ts -> ${esVersion}) pino.transport with file URL`, async ({ same, teardown }) => {
+    const destination = join(
+      os.tmpdir(),
+      '_' + Math.random().toString(36).substr(2, 9)
+    )
+    const transport = pino.transport({
+      target: url.pathToFileURL(join(__dirname, '..', 'fixtures', 'ts', `to-file-transport.${esVersion}.cjs`)).href,
+      options: { destination }
+    })
+    teardown(transport.end.bind(transport))
+    const instance = pino(transport)
+    instance.info('hello')
+    await watchFileCreated(destination)
+    const result = JSON.parse(await readFile(destination, { encoding: 'utf8' }))
+    delete result.time
+    same(result, {
+      pid,
+      hostname,
+      level: 30,
+      msg: 'hello'
+    })
+  })
+
+  test(`(ts -> ${esVersion}) pino.transport with two files`, async ({ same, teardown }) => {
+    const dest1 = join(
+      os.tmpdir(),
+      '_' + Math.random().toString(36).substr(2, 9)
+    )
+    const dest2 = join(
+      os.tmpdir(),
+      '_' + Math.random().toString(36).substr(2, 9)
+    )
+    const transport = pino.transport({
+      targets: [{
+        level: 'info',
+        target: join(__dirname, '..', 'fixtures', 'ts', `to-file-transport.${esVersion}.cjs`),
+        options: { destination: dest1 }
+      }, {
+        level: 'info',
+        target: join(__dirname, '..', 'fixtures', 'ts', `to-file-transport.${esVersion}.cjs`),
+        options: { destination: dest2 }
+      }]
+    })
+
+    teardown(transport.end.bind(transport))
+
+    const instance = pino(transport)
+    instance.info('hello')
+
+    await Promise.all([watchFileCreated(dest1), watchFileCreated(dest2)])
+
+    const result1 = JSON.parse(await readFile(dest1, { encoding: 'utf8' }))
+    delete result1.time
+    same(result1, {
+      pid,
+      hostname,
+      level: 30,
+      msg: 'hello'
+    })
+    const result2 = JSON.parse(await readFile(dest2, { encoding: 'utf8' }))
+    delete result2.time
+    same(result2, {
+      pid,
+      hostname,
+      level: 30,
+      msg: 'hello'
+    })
+  })
+}
+
+runTests('es5')
+runTests('es6')
+runTests('es2017')
+runTests('esnext')
diff --git a/tsconfig.json b/tsconfig.json
index 05e9370ee..fd185a0b2 100644
--- a/tsconfig.json
+++ b/tsconfig.json
@@ -5,6 +5,7 @@
     "module": "commonjs",
     "noEmit": true,
     "strict": true,
+    "esModuleInterop": true,
   },
   "exclude": [
     "./test/types/*.test-d.ts",