diff --git a/.changeset/fix-comlink-dispose-listener.md b/.changeset/fix-comlink-dispose-listener.md
new file mode 100644
index 000000000..c407afdc2
--- /dev/null
+++ b/.changeset/fix-comlink-dispose-listener.md
@@ -0,0 +1,5 @@
+---
+"@powersync/web": patch
+---
+
+Avoid binding `this` when disposing table change listeners in the web adapter to prevent Comlink serialization errors on close.
diff --git a/packages/web/src/db/adapters/LockedAsyncDatabaseAdapter.ts b/packages/web/src/db/adapters/LockedAsyncDatabaseAdapter.ts
index 2b1f2221a..4a46e3a9c 100644
--- a/packages/web/src/db/adapters/LockedAsyncDatabaseAdapter.ts
+++ b/packages/web/src/db/adapters/LockedAsyncDatabaseAdapter.ts
@@ -170,7 +170,10 @@ export class LockedAsyncDatabaseAdapter
    */
   async close() {
     this.closing = true;
-    this._disposeTableChangeListener?.();
+    const dispose = this._disposeTableChangeListener;
+    if (dispose) {
+      dispose();
+    }
     this.pendingAbortControllers.forEach((controller) => controller.abort('Closed'));
     await this.baseDB?.close?.();
     this.closed = true;
diff --git a/packages/web/tests/locked_adapter_close.test.ts b/packages/web/tests/locked_adapter_close.test.ts
new file mode 100644
index 000000000..e7bafa7cd
--- /dev/null
+++ b/packages/web/tests/locked_adapter_close.test.ts
@@ -0,0 +1,56 @@
+import { describe, expect, it } from 'vitest';
+import { LockedAsyncDatabaseAdapter } from '../src/db/adapters/LockedAsyncDatabaseAdapter';
+import { AsyncDatabaseConnection } from '../src/db/adapters/AsyncDatabaseConnection';
+import { DEFAULT_CACHE_SIZE_KB, TemporaryStorageOption } from '../src/db/adapters/web-sql-flags';
+import { ResolvedWASQLiteOpenFactoryOptions } from '../src/db/adapters/wa-sqlite/WASQLiteOpenFactory';
+import { WASQLiteVFS } from '../src/db/adapters/wa-sqlite/WASQLiteConnection';
+
+describe('LockedAsyncDatabaseAdapter.close', () => {
+  it('calls the table change disposer without binding this', async () => {
+    let thisValue: unknown;
+    let called = false;
+
+    const disposer = function (this: unknown) {
+      thisValue = this;
+      called = true;
+    };
+
+    const config: ResolvedWASQLiteOpenFactoryOptions = {
+      dbFilename: 'test.db',
+      flags: {
+        broadcastLogs: true,
+        disableSSRWarning: false,
+        enableMultiTabs: false,
+        useWebWorker: false,
+        ssrMode: false
+      },
+      temporaryStorage: TemporaryStorageOption.MEMORY,
+      cacheSizeKb: DEFAULT_CACHE_SIZE_KB,
+      vfs: WASQLiteVFS.OPFSCoopSyncVFS
+    };
+
+    const db: AsyncDatabaseConnection = {
+      init: async () => {},
+      close: async () => {},
+      markHold: async () => 'hold',
+      releaseHold: async () => {},
+      isAutoCommit: async () => true,
+      execute: async () => ({ rows: { _array: [], length: 0 } } as any),
+      executeRaw: async () => [],
+      executeBatch: async () => ({ rows: { _array: [], length: 0 } } as any),
+      registerOnTableChange: async () => disposer,
+      getConfig: async () => config
+    };
+
+    const adapter = new LockedAsyncDatabaseAdapter({
+      name: 'test-close',
+      openConnection: async () => db
+    });
+
+    await adapter.init();
+    await adapter.close();
+
+    expect(called).toBe(true);
+    expect(thisValue).toBeUndefined();
+  });
+});