diff --git a/.changeset/opfs-pagehide-worker-terminate.md b/.changeset/opfs-pagehide-worker-terminate.md
new file mode 100644
index 000000000..3eff3e1a6
--- /dev/null
+++ b/.changeset/opfs-pagehide-worker-terminate.md
@@ -0,0 +1,5 @@
+---
+"@powersync/web": patch
+---
+
+Defer dedicated OPFS worker termination on pagehide until open completes and ignore repeat pagehide events to avoid lock leaks.
diff --git a/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts b/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts
index e03bf8aa8..47b2803bf 100644
--- a/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts
+++ b/packages/web/src/db/adapters/WorkerWrappedAsyncDatabaseConnection.ts
@@ -32,6 +32,7 @@ export class WorkerWrappedAsyncDatabaseConnection<Config extends ResolvedWebSQLO
 {
   protected lockAbortController = new AbortController();
   protected notifyRemoteClosed: AbortController | undefined;
+  private finalized = false;
 
   constructor(protected options: WrappedWorkerConnectionOptions<Config>) {
     if (options.remoteCanCloseUnexpectedly) {
@@ -160,14 +161,33 @@ export class WorkerWrappedAsyncDatabaseConnection<Config extends ResolvedWebSQLO
     return this.baseConnection.registerOnTableChange(Comlink.proxy(callback));
   }
 
+  private finalizeClose(): void {
+    if (this.finalized) {
+      return;
+    }
+    this.finalized = true;
+    // Ensure cleanup is idempotent if close is triggered from multiple paths.
+    this.notifyRemoteClosed?.abort();
+    try {
+      this.options.remote[Comlink.releaseProxy]();
+    } catch {
+      // Proxy can already be released on teardown.
+    }
+    this.options.onClose?.();
+  }
+
+  forceClose(): void {
+    this.lockAbortController.abort();
+    this.finalizeClose();
+  }
+
   async close(): Promise<void> {
     // Abort any pending lock requests.
     this.lockAbortController.abort();
     try {
       await this.withRemote(() => this.baseConnection.close());
     } finally {
-      this.options.remote[Comlink.releaseProxy]();
-      this.options.onClose?.();
+      this.finalizeClose();
     }
   }
 
diff --git a/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts b/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts
index 487d121aa..6691f4a4f 100644
--- a/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts
+++ b/packages/web/src/db/adapters/wa-sqlite/WASQLiteOpenFactory.ts
@@ -57,6 +57,8 @@ export class WASQLiteOpenFactory extends AbstractWebSQLOpenFactory {
       cacheSizeKb = DEFAULT_CACHE_SIZE_KB,
       encryptionKey
     } = this.waOptions;
+    const shouldForceCloseOnPagehide =
+      vfs === WASQLiteVFS.OPFSCoopSyncVFS || vfs === WASQLiteVFS.AccessHandlePoolVFS;
 
     if (!enableMultiTabs) {
       this.logger.warn('Multiple tabs are not enabled in this browser');
@@ -80,11 +82,42 @@ export class WASQLiteOpenFactory extends AbstractWebSQLOpenFactory {
 
       const workerDBOpener = Comlink.wrap<OpenAsyncDatabaseConnection<WorkerDBOpenerOptions>>(workerPort);
 
-      return new WorkerWrappedAsyncDatabaseConnection({
-        remote: workerDBOpener,
-        // This tab owns the worker, so we're guaranteed to outlive it.
-        remoteCanCloseUnexpectedly: false,
-        baseConnection: await workerDBOpener({
+      let pagehideHandler: ((event: PageTransitionEvent) => void) | null = null;
+      let pagehideTriggered = false;
+      let wrapped: WorkerWrappedAsyncDatabaseConnection<WorkerDBOpenerOptions> | null = null;
+      const terminateWorker = () => {
+        if (workerPort instanceof Worker) {
+          workerPort.terminate();
+        } else {
+          workerPort.close();
+        }
+      };
+      const cleanupPagehide = () => {
+        if (pagehideHandler && typeof window !== 'undefined') {
+          window.removeEventListener('pagehide', pagehideHandler);
+          pagehideHandler = null;
+        }
+      };
+
+      if (shouldForceCloseOnPagehide && workerPort instanceof Worker && typeof window !== 'undefined') {
+        // Register early so refresh/navigation during open still releases OPFS locks.
+        pagehideHandler = (_event: PageTransitionEvent) => {
+          if (pagehideTriggered) {
+            return;
+          }
+          pagehideTriggered = true;
+          if (wrapped) {
+            wrapped.forceClose();
+            return;
+          }
+          // Defer termination until open completes so OPFS locks can be released.
+        };
+        window.addEventListener('pagehide', pagehideHandler);
+      }
+
+      let baseConnection: AsyncDatabaseConnection;
+      try {
+        baseConnection = await workerDBOpener({
           dbFilename: this.options.dbFilename,
           vfs,
           temporaryStorage,
@@ -92,16 +125,31 @@ export class WASQLiteOpenFactory extends AbstractWebSQLOpenFactory {
           flags: this.resolvedFlags,
           encryptionKey: encryptionKey,
           logLevel: this.logger.getLevel()
-        }),
+        });
+      } catch (error) {
+        cleanupPagehide();
+        terminateWorker();
+        throw error;
+      }
+
+      const connection = new WorkerWrappedAsyncDatabaseConnection<WorkerDBOpenerOptions>({
+        remote: workerDBOpener,
+        // This tab owns the worker, so we're guaranteed to outlive it.
+        remoteCanCloseUnexpectedly: false,
+        baseConnection,
         identifier: this.options.dbFilename,
         onClose: () => {
-          if (workerPort instanceof Worker) {
-            workerPort.terminate();
-          } else {
-            workerPort.close();
-          }
+          cleanupPagehide();
+          terminateWorker();
         }
       });
+      wrapped = connection;
+
+      if (pagehideTriggered) {
+        connection.forceClose();
+      }
+
+      return connection;
     } else {
       // Don't use a web worker
       return new WASqliteConnection({
diff --git a/packages/web/tests/opfs_pagehide.test.ts b/packages/web/tests/opfs_pagehide.test.ts
new file mode 100644
index 000000000..7fb005978
--- /dev/null
+++ b/packages/web/tests/opfs_pagehide.test.ts
@@ -0,0 +1,165 @@
+import { afterEach, beforeEach, describe, expect, it, vi } from 'vitest';
+import type { AsyncDatabaseConnection } from '../src/db/adapters/AsyncDatabaseConnection';
+import {
+  DEFAULT_WEB_SQL_FLAGS,
+  TemporaryStorageOption,
+  type ResolvedWebSQLOpenOptions
+} from '../src/db/adapters/web-sql-flags';
+
+let WASQLiteOpenFactory: typeof import('@powersync/web').WASQLiteOpenFactory;
+let WASQLiteVFS: typeof import('@powersync/web').WASQLiteVFS;
+
+let nextOpenPromise: Promise<unknown> | null = null;
+const baseConfig: ResolvedWebSQLOpenOptions = {
+  dbFilename: 'crm.sqlite',
+  flags: DEFAULT_WEB_SQL_FLAGS,
+  temporaryStorage: TemporaryStorageOption.MEMORY,
+  cacheSizeKb: 1
+};
+
+const baseConnection: AsyncDatabaseConnection = {
+  init: async () => {},
+  close: async () => {},
+  markHold: async () => 'hold',
+  releaseHold: async () => {},
+  isAutoCommit: async () => true,
+  execute: async () => ({ rows: { _array: [], length: 0 }, rowsAffected: 0, insertId: 0 }),
+  executeRaw: async () => [],
+  executeBatch: async () => ({ rows: { _array: [], length: 0 }, rowsAffected: 0, insertId: 0 }),
+  registerOnTableChange: async () => () => {},
+  getConfig: async () => baseConfig
+};
+
+vi.mock('comlink', async () => {
+  const actual = await vi.importActual<typeof import('comlink')>('comlink');
+  return {
+    ...actual,
+    wrap: () => {
+      const opener = (() => nextOpenPromise ?? Promise.resolve(baseConnection)) as unknown as ReturnType<
+        typeof actual.wrap
+      >;
+      opener[actual.releaseProxy] = () => {};
+      return opener;
+    }
+  };
+});
+
+describe('OPFS pagehide cleanup', { sequential: true }, () => {
+  let originalWorker: typeof Worker;
+  let workers: Worker[] = [];
+  let terminated = false;
+  let terminateCount = 0;
+
+  beforeEach(() => {
+    terminated = false;
+    terminateCount = 0;
+    workers = [];
+    nextOpenPromise = null;
+    originalWorker = window.Worker;
+    window.Worker = new Proxy(originalWorker, {
+      construct(target, args) {
+        const instance = new target(...(args as ConstructorParameters<typeof Worker>));
+        workers.push(instance);
+        const originalTerminate = instance.terminate.bind(instance);
+        instance.terminate = () => {
+          terminated = true;
+          terminateCount += 1;
+          return originalTerminate();
+        };
+        return instance;
+      }
+    });
+  });
+
+  afterEach(() => {
+    workers.forEach((worker) => {
+      try {
+        worker.terminate();
+      } catch {
+        // Ignore termination errors during cleanup.
+      }
+    });
+    window.Worker = originalWorker;
+  });
+
+  beforeEach(async () => {
+    ({ WASQLiteOpenFactory, WASQLiteVFS } = await import('@powersync/web'));
+  });
+
+  it('terminates dedicated worker on pagehide for OPFS VFS', async () => {
+    const factory = new WASQLiteOpenFactory({
+      dbFilename: `pagehide-${crypto.randomUUID()}.db`,
+      vfs: WASQLiteVFS.OPFSCoopSyncVFS,
+      flags: { enableMultiTabs: false, useWebWorker: true }
+    });
+
+    await factory.openConnection();
+
+    const cached = new Event('pagehide') as PageTransitionEvent;
+    Object.defineProperty(cached, 'persisted', { value: true });
+    window.dispatchEvent(cached);
+
+    expect(terminated).toBe(true);
+  });
+
+  it('defers termination until open completes when pagehide fires during open for OPFS VFS', async () => {
+    let resolveOpen!: (connection: unknown) => void;
+    nextOpenPromise = new Promise<unknown>((resolve) => {
+      resolveOpen = resolve;
+    });
+
+    const factory = new WASQLiteOpenFactory({
+      dbFilename: `pagehide-${crypto.randomUUID()}.db`,
+      vfs: WASQLiteVFS.OPFSCoopSyncVFS,
+      flags: { enableMultiTabs: false, useWebWorker: true }
+    });
+
+    const openTask = factory.openConnection();
+
+    const pagehide = new Event('pagehide') as PageTransitionEvent;
+    window.dispatchEvent(pagehide);
+    const terminatedAfterPagehide = terminated;
+
+    resolveOpen(baseConnection);
+    await openTask;
+    await Promise.resolve();
+
+    expect(terminatedAfterPagehide).toBe(false);
+    expect(terminated).toBe(true);
+  });
+
+  it('ignores repeated pagehide events during open for OPFS VFS', async () => {
+    let resolveOpen!: (connection: unknown) => void;
+    nextOpenPromise = new Promise<unknown>((resolve) => {
+      resolveOpen = resolve;
+    });
+
+    const factory = new WASQLiteOpenFactory({
+      dbFilename: `pagehide-${crypto.randomUUID()}.db`,
+      vfs: WASQLiteVFS.OPFSCoopSyncVFS,
+      flags: { enableMultiTabs: false, useWebWorker: true }
+    });
+
+    const openTask = factory.openConnection();
+
+    const firstPagehide = new Event('pagehide') as PageTransitionEvent;
+    window.dispatchEvent(firstPagehide);
+    const terminatedAfterFirst = terminated;
+    const terminateCountAfterFirst = terminateCount;
+
+    const secondPagehide = new Event('pagehide') as PageTransitionEvent;
+    window.dispatchEvent(secondPagehide);
+    const terminatedAfterSecond = terminated;
+    const terminateCountAfterSecond = terminateCount;
+
+    resolveOpen(baseConnection);
+    await openTask;
+    await Promise.resolve();
+
+    expect(terminatedAfterFirst).toBe(false);
+    expect(terminatedAfterSecond).toBe(false);
+    expect(terminateCountAfterFirst).toBe(0);
+    expect(terminateCountAfterSecond).toBe(0);
+    expect(terminateCount).toBe(1);
+  });
+});