diff --git a/compiler/src/dotty/tools/dotc/inlines/Inlines.scala b/compiler/src/dotty/tools/dotc/inlines/Inlines.scala
index 859648a47c6a..48d8530751eb 100644
--- a/compiler/src/dotty/tools/dotc/inlines/Inlines.scala
+++ b/compiler/src/dotty/tools/dotc/inlines/Inlines.scala
@@ -76,9 +76,23 @@ object Inlines:
           case _ => false
         tree.symbol.name.isUnapplyName && rec(tree)
 
-      isInlineable(tree.symbol)
+      val sym = tree.symbol
+      sym.is(Inline) && sym.hasAnnotation(defn.BodyAnnot)
       && !tree.tpe.widenTermRefExpr.isInstanceOf[MethodOrPoly]
       && StagingLevel.level == 0
+      && (
+        // Outside of inline method bodies, any inline call may be inlined.
+        !inInlineMethod
+        // Inside inline method bodies, a transparent inline given must still be
+        // expanded at typer so that dependent type members of its result
+        // (e.g. `tc.Out` from `fromVal[Int, Int]`) are known when typing the
+        // enclosing body; otherwise the implicit-argument reference is
+        // non-stable and gets skolemized, making `tc.Out` opaque. See #15798.
+        // Macro-based givens are excluded: eager expansion of their bodies
+        // would run a macro at the def site with abstract types, typically
+        // causing cyclic-macro-dependency errors (see tests/neg-macros/i18695).
+        || (sym.is(Given) && !sym.is(Macro) && needsTransparentInlining(tree))
+      )
       && (
         ctx.phase == Phases.inliningPhase
         || (ctx.phase == Phases.typerPhase && needsTransparentInlining(tree))
diff --git a/tests/pos/i15798.scala b/tests/pos/i15798.scala
new file mode 100644
index 000000000000..1020832b55e6
--- /dev/null
+++ b/tests/pos/i15798.scala
@@ -0,0 +1,25 @@
+import compiletime.ops.*
+
+class Inlined[T](val value : T)
+object Inlined:
+  trait TC[UB, R]:
+    type Out <: UB
+    def apply(arg: R): Inlined[Out]
+  object TC:
+    transparent inline given fromVal[UB, R <: UB]: TC[UB, R] = new TC[UB, R]:
+      type Out = R
+      def apply(arg: R): Inlined[R] = forced[R](arg)
+    transparent inline given fromInline[UB, R <: UB, I <: Inlined[R]]: TC[UB, I] =
+      new TC[UB, I]:
+        type Out = R
+        def apply(arg: I): Inlined[R] = arg
+
+  protected inline def forced[T](_value: Any): Inlined[T] = Inlined[T](_value.asInstanceOf[T])
+
+  def add[T <: Int, R](lhs: Inlined[T], rhs: R)(using tc: TC[Int, R]) =
+      forced[int.+[T, tc.Out]](lhs.value + tc(rhs).value)
+  def get[T <: Int](inlined: Inlined[T]) : T = inlined.value
+
+object Test:
+  inline def check[UB <: Int](ub: Inlined[UB]): Unit =
+    val y = Inlined.get(Inlined.add(ub, 1))