diff --git a/requirements/REQUIREMENTS-CI.txt b/requirements/REQUIREMENTS-CI.txt
index 4db5c12d..10a72a12 100644
--- a/requirements/REQUIREMENTS-CI.txt
+++ b/requirements/REQUIREMENTS-CI.txt
@@ -155,7 +155,7 @@ types-setuptools==80.9.0.20250822
 types-urllib3==1.26.25.14
 typing_extensions==4.15.0
 tzdata==2025.2
-urllib3==1.26.20
+urllib3==2.6.0
 validators==0.35.0
 wcwidth==0.2.14
 webencodings==0.5.1
diff --git a/requirements/REQUIREMENTS-JUPYTER.txt b/requirements/REQUIREMENTS-JUPYTER.txt
index 4dbe8314..833a0989 100644
--- a/requirements/REQUIREMENTS-JUPYTER.txt
+++ b/requirements/REQUIREMENTS-JUPYTER.txt
@@ -134,7 +134,7 @@ traitlets==5.14.3
 typing_extensions==4.15.0
 tzdata==2025.2
 uri-template==1.3.0
-urllib3==1.26.20
+urllib3==2.6.0
 validators==0.35.0
 wcwidth==0.2.14
 webcolors==24.11.1
diff --git a/requirements/REQUIREMENTS-NAPARI-CI.txt b/requirements/REQUIREMENTS-NAPARI-CI.txt
index 6e0db165..9acdc7c8 100644
--- a/requirements/REQUIREMENTS-NAPARI-CI.txt
+++ b/requirements/REQUIREMENTS-NAPARI-CI.txt
@@ -154,7 +154,7 @@ typer==0.20.0
 typing-inspection==0.4.2
 typing_extensions==4.15.0
 tzdata==2025.2
-urllib3==1.26.20
+urllib3==2.6.0
 validators==0.35.0
 vispy==0.14.3
 wcwidth==0.2.14
diff --git a/starfish/REQUIREMENTS-STRICT.txt b/starfish/REQUIREMENTS-STRICT.txt
index 58d42f58..05452f00 100644
--- a/starfish/REQUIREMENTS-STRICT.txt
+++ b/starfish/REQUIREMENTS-STRICT.txt
@@ -53,7 +53,7 @@ tqdm==4.67.1
 trackpy==0.7
 typing_extensions==4.15.0
 tzdata==2025.2
-urllib3==1.26.20
+urllib3==2.6.0
 validators==0.35.0
 xarray==2024.7.0
 zipp==3.23.0