projection_groups.jsonl

{"id": "kind_excitatory", "mode": "kind", "key": "excitatory", "name": "Glutamate", "description": "The brain's main excitatory transmitter: glutamatergic projections drive their targets, including the corticostriatal and thalamocortical pathways.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Glutamate_(neurotransmitter)", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_209ad2389cd7", "provenance": "verified"}]}
{"id": "kind_inhibitory", "mode": "kind", "key": "inhibitory", "name": "GABA", "description": "The brain's main inhibitory transmitter: GABAergic projections suppress their targets, including the striatal output of the basal ganglia.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Gamma-Aminobutyric_acid", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_5917dc04b662", "provenance": "verified"}]}
{"id": "kind_dopaminergic", "mode": "kind", "key": "dopaminergic", "name": "Dopamine", "description": "Dopaminergic projections from the midbrain (substantia nigra, VTA) modulate movement, motivation and reward.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Dopaminergic_pathways", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_6d2a1ac8fd34", "provenance": "verified"}]}
{"id": "kind_cholinergic", "mode": "kind", "key": "cholinergic", "name": "Acetylcholine", "description": "Cholinergic projections modulate arousal, attention and memory across the cortex and hippocampus.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Cholinergic", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_da6f20978229", "provenance": "verified"}]}
{"id": "kind_neuroendocrine", "mode": "kind", "key": "neuroendocrine", "name": "Releasing hormones", "description": "Hypothalamic neuroendocrine projections release hormones that control the pituitary and the body's endocrine axes.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Releasing_hormone", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_9b2234c0a457", "provenance": "verified"}]}
{"id": "kind_serotonergic", "mode": "kind", "key": "serotonergic", "name": "Serotonin", "description": "Serotonergic projections from the raphe nuclei diffusely modulate mood, sleep and appetite throughout the brain.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Serotonergic", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_17907a37530d", "provenance": "verified"}]}
{"id": "kind_noradrenergic", "mode": "kind", "key": "noradrenergic", "name": "Noradrenaline", "description": "Noradrenergic projections from the locus coeruleus modulate arousal, vigilance and the stress response.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Norepinephrine", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_5f60a626871f", "provenance": "verified"}]}
{"id": "kind_histaminergic", "mode": "kind", "key": "histaminergic", "name": "Histamine", "description": "Histaminergic projections from the tuberomammillary nucleus promote wakefulness and arousal across the cortex and thalamus.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Histaminergic", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_7fd242a6f8aa", "provenance": "verified"}]}
{"id": "sign_excitatory", "mode": "sign", "key": "excitatory", "name": "Excitatory", "description": "Excitatory pathways depolarize their target, making it more likely to fire (mainly glutamatergic).", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Excitatory_postsynaptic_potential", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_209ad2389cd7", "provenance": "verified"}]}
{"id": "sign_inhibitory", "mode": "sign", "key": "inhibitory", "name": "Inhibitory", "description": "Inhibitory pathways hyperpolarize their target, making it less likely to fire (mainly GABAergic).", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Inhibitory_postsynaptic_potential", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_5917dc04b662", "provenance": "verified"}]}
{"id": "sign_modulatory", "mode": "sign", "key": "modulatory", "name": "Modulatory", "description": "Modulatory pathways (the monoamines and acetylcholine) tune the gain and excitability of their targets rather than directly exciting or inhibiting them.", "classification_provenance": "llm", "wikipedia": "https://en.wikipedia.org/wiki/Neuromodulation", "wikipedia_provenance": "sourced", "sources": [{"quote_id": "q_10389c0a737b", "provenance": "verified"}]}