diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 9db4b42..1fd1b09 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -63,11 +63,17 @@ jobs:
             tox: pyqt5
           - name: PySide2
             tox: pyside2
+          - name: PySide6
+            tox: pyside6
         exclude:
           - python:
               tox: py39
             os:
               python_platform: win32
+          - python:
+              tox: py35
+            wrapper:
+              tox: pyside6
     steps:
       - uses: actions/checkout@v2
       - name: Set up ${{ matrix.python.name }}
diff --git a/setup.py b/setup.py
index e87c133..8165bab 100644
--- a/setup.py
+++ b/setup.py
@@ -50,6 +50,9 @@ def read(fname):
             #   https://github.com/pytest-dev/pytest-twisted/pull/107#issuecomment-643679361
             "pyside2 != 5.15.0",
         ],
+        "pyside6": [
+            "pyside6",
+        ],
         "test": [
             "coverage",
             "pytest",
diff --git a/src/qt5reactor/core.py b/src/qt5reactor/core.py
index 7ff8aae..de961b3 100644
--- a/src/qt5reactor/core.py
+++ b/src/qt5reactor/core.py
@@ -118,9 +118,15 @@
             QCoreApplication, QEventLoop, QObject, QSocketNotifier, QTimer,
         )
     except ImportError as e1:
-        raise ImportError(
-            "Neither PyQt5 nor PySide2 installed.\nPyQt5: {}\nPySide2: {})".format(e0, e1)
-        )
+        try:
+            # try PySide6
+            from PySide6.QtCore import (
+                QCoreApplication, QEventLoop, QObject, QSocketNotifier, QTimer,
+            )
+        except ImportError as e2:
+            raise ImportError(
+                "Neither PyQt5, PySide2 nor PySide6 installed.\nPyQt5: {}\nPySide2: {}\nPySide6: {})".format(e0, e1, e2)
+            )
 
 from twisted.internet.error import ReactorAlreadyInstalledError
 from twisted.internet import posixbase
diff --git a/tox.ini b/tox.ini
index 5db3135..4b99191 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 minversion=3.1
-envlist = py{35,36,37}-py{qt5,side2}
+envlist = py{35,36,37,38,39}-py{qt5,side2},py{36,37,38,39}-pyside6
 
 [testenv]
 deps=
@@ -10,6 +10,7 @@ deps=
     pyqt5: PyQt5-sip==12.8.0
 
     pyside2: pyside2==5.15.1
+    pyside6: pyside6==6.1.3
 
 passenv=
     TOXENV