Integrating multimodal clinical data, multi-omics, computational inference, and mechanistic biology to decode complex chronic diseases.
Zhengzhou University · Cardiovascular Medicine · Computational Biomedicine
Academic Website · Google Scholar · ORCID · ResearchGate
I study how disease heterogeneity emerges across clinical, molecular, cellular, and temporal scales, with particular emphasis on atherosclerosis, vascular smooth muscle cell plasticity, and circadian disruption.
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01 · CLINICAL INTELLIGENCE AI for Science & Multimodal Clinical Intelligence Interpretable models for population-scale risk stratification and discovery. |
02 · VASCULAR SYSTEMS Atherosclerosis & Vascular Systems Biology Plaque vulnerability, vascular microenvironments, and smooth muscle cell plasticity. |
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03 · CROSS-SCALE OMICS Multi-omics & Translational Discovery Cross-scale integration to resolve heterogeneity and prioritize mechanistic drivers. |
04 · TEMPORAL BIOLOGY Circadian Disruption & Disease Biology Circadian dysregulation linking molecular states, vascular dysfunction, and disease progression. |
| Research | Domain | Scientific Contribution |
|---|---|---|
| AIHFLevel | Clinical AI · Heart failure | Interpretable multicenter survival assessment and individualized risk stratification. |
| APVS | Atherosclerosis · Plaque biology | Biologically interpretable quantification of plaque vulnerability. |
| ClockProCRC | Circadian systems biology · Cancer | Cross-cohort inference of circadian misalignment and molecular clock states. |
| KIF13B | Vascular biology · VSMC fate | Mechanistic resolution of a VSMC state axis governing plaque stability. |
| LDL | Atherosclerosis · State transitions | Transition signals and high-resolution networks across lesion states. |
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AI hybrid survival assessment for advanced heart failure patients with renal dysfunction
Nature Communications · 2024 -
Vascular smooth muscle cell-derived KIF13B inhibits proinflammatory responses to protect against atherosclerosis
Journal of Clinical Investigation · 2026 -
System biology analysis reveals circadian rhythm disorder associated with development and progression in colorectal cancer
npj Precision Oncology · 2026 -
Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability
iScience · 2023
Explore the complete, maintained record on the Academic Website or Google Scholar.
Clinical phenotypes → cross-scale omics → computational inference → mechanistic discovery → translation.
- Clinical Intelligence — AIHFLevel
- Vascular Systems Biology — APVS · KIF13B · LDL
- Circadian Computing — ClockProCRC
For the full research record, publication-level resources, and current scientific program, visit drgezhang.com. Persistent identity: ORCID 0000-0002-3116-3246.
