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Cross-Cohort Prediction of Dental Caries and Periodontitis from Salivary Shotgun Metagenome Data

This repository contains the analysis code and Jupyter notebooks associated with the manuscript “Cross-Cohort Prediction of Dental Caries and Periodontitis from Salivary Shotgun Metagenome Data.”

The repository includes workflows for:

  • technical quality control and exploratory analysis;
  • taxonomic and functional diversity analysis;
  • differential abundance analysis;
  • cross-validation, leave-one-study-out evaluation, and SHAP interpretation;
  • generation of the main and supplementary figures.

Input data are not included in the repository. Data and output paths can be configured in config.py or through the SALIVARY_WGS_DATA_DIR and SALIVARY_WGS_OUTPUT_DIR environment variables.

Citation details will be added after publication.

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MIT License.

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