This repository contains MATLAB simulation code for the paper:
"Quantitative Macromolecular Proton Fraction Imaging using Pulsed Spin-Lock"
Authors: Qianxue Shan, Ziqiang Yu, Baiyan Jiang, Jian Hou, Qiuyi Shen, Winnie Chiu-Wing Chu, Vincent Wai-Sun Wong, Weitian Chen
This repository provides the simulation framework for quantitative macromolecular proton fraction (MPF) imaging using pulsed spin-lock techniques (MPF-PSL).
The main scripts are:
Simulation_study_1.m: Demo script for Simulation Study 1 in the MPF-PSL paper.
This script investigates the sensitivity of the quantitative measurements ( R_{mpfsl} ) and ( R_{mpfsl,pul} ) to various tissue parameters, including ( R_{1a} ), ( R_{2a} ), ( T_{2b} ), ( K_{ca} ), and ( f_b ).Simulation_study_2.m: Demo script for Simulation Study 2 in the MPF-PSL paper.
This script investigates how the Relative Measurement Precision (RMP) changes with increasing spin-lock duration.
Other functions and scripts provide:
- Definition of tissue and sequence parameters for liver and other biological tissues.
- Numerical simulation of magnetization evolution based on the Bloch-McConnell equations under various spin-lock and adiabatic pulse conditions.
- Generation of adiabatic half-passage (AHP) and reverse AHP pulses.
The code is intended for academic and research use, facilitating the quantitative analysis of MPF imaging using advanced spin-lock techniques.
If you use this code or results in your research, please cite our paper:
Shan Q, Yu Z, Jiang B, Hou J, Shen Q, Chu WCW, Wong VWS, Chen W. Quantitative macromolecular proton fraction imaging using pulsed spin-lock. Magn Reson Med. 2025 Dec;94(6):2492-2507. doi: 10.1002/mrm.70021. Epub 2025 Aug 5. PMID: 40762173; PMCID: PMC12501701.
This code is for academic and research purposes only. Commercial use or redistribution is strictly prohibited without explicit written permission from the authors.