feat(app): manually build indeterminate guideline for FDA fallbacks

hpi-dhc · Feb 27, 2025 · e88fa68 · e88fa68
1 parent ca59946
commit e88fa68
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Showing 6 changed files with 55 additions and 9 deletions.
diff --git a/app/integration_test/drugs_test.dart b/app/integration_test/drugs_test.dart
@@ -153,7 +153,7 @@ void main() {
         findsOneWidget,
       );
       expect(
-        find.textContaining(context.l10n.drugs_page_no_guidelines_text),
+        find.textContaining(context.l10n.drugs_page_no_guidelines_recommendation_text),
         findsOneWidget,
       );
       if (drug.guidelines.isNotEmpty) {

diff --git a/app/lib/common/models/drug/drug.dart b/app/lib/common/models/drug/drug.dart
@@ -2,6 +2,7 @@ import 'package:freezed_annotation/freezed_annotation.dart';
 import 'package:hive/hive.dart';
 import 'package:trotter/trotter.dart';
 
+import '../../../app.dart';
 import '../../module.dart';
 
 part 'drug.g.dart';
@@ -106,7 +107,7 @@ extension DrugExtension on Drug {
       ),
     );
     if (partialGuidelines.isEmpty) return null;
-    final guidelineGenes = guidelines.first.lookupkey.keys.toList();
+    final guidelineGenes = guidelines.first.genes;
     Guideline? partiallyHandledGuideline;
     var currentMatchingNumber = guidelineGenes.length - 1;
     while (currentMatchingNumber > 0 && partiallyHandledGuideline == null) {
@@ -142,13 +143,40 @@ extension DrugExtension on Drug {
     if (exactGuideline != null) return exactGuideline;
     final partiallyHandledGuideline = _getPartiallyHandledGuideline();
     if (partiallyHandledGuideline != null) return partiallyHandledGuideline;
-    return guidelines.firstOrNullWhere(
+    final completelyUnhandledGuideline = guidelines.firstOrNullWhere(
       (guideline) => guideline.lookupkey.all(
         (gene, variants) => variants.any(
           (variant) => variant == SpecialLookup.anyNotHandled.value
         )
-      ),
+      )
     );
+    final context = PharMeApp.navigatorKey.currentContext;
+    if (
+      completelyUnhandledGuideline != null &&
+      completelyUnhandledGuideline.isFdaGuideline &&
+      context != null
+    ) {      
+      final isCompletelyIndeterminateResult = guidelineGenotypes.map(
+        (genotypeKey) => UserData.instance.genotypeResults?[genotypeKey]
+      ).all(
+        (genotypeResult) =>
+          genotypeResult != null &&
+          genotypeResult.phenotypeDisplayString(context) == indeterminateResult
+      );
+      if (isCompletelyIndeterminateResult) {
+        final indeterminateFdaFallbackGuideline = Guideline.fromJson(
+          completelyUnhandledGuideline.toJson(),
+        );
+        indeterminateFdaFallbackGuideline.annotations.implication =
+          context.l10n.drugs_page_fda_indeterminate_implication_text(name);
+        indeterminateFdaFallbackGuideline.annotations.recommendation = 
+          context.l10n.drugs_page_no_guidelines_recommendation_text;
+        indeterminateFdaFallbackGuideline.annotations.warningLevel =
+          WarningLevel.none;
+        return indeterminateFdaFallbackGuideline;
+      }
+    }
+    return completelyUnhandledGuideline;
   }
 
   Guideline? get userOrFirstGuideline => userGuideline ??

diff --git a/app/lib/common/models/drug/guideline.dart b/app/lib/common/models/drug/guideline.dart
@@ -6,7 +6,7 @@ part 'guideline.g.dart';
 
 @HiveType(typeId: 8)
 @JsonSerializable()
-class Guideline {
+class  Guideline {
   Guideline({
     required this.id,
     required this.version,
@@ -16,6 +16,12 @@ class Guideline {
   });
   factory Guideline.fromJson(dynamic json) => _$GuidelineFromJson(json);
 
+  Map<String,dynamic> toJson() => _$GuidelineToJson(this);
+
+  bool get isFdaGuideline => externalData.first.source == 'FDA';
+
+  List<String> get genes => lookupkey.keys.toList();
+
   @HiveField(0)
   @JsonKey(name: '_id')
   String id;

diff --git a/app/lib/common/utilities/pdf_utils.dart b/app/lib/common/utilities/pdf_utils.dart
@@ -221,7 +221,7 @@ List<pw.Widget> _buildUserPart(
   final userGuidelineText = drug.userGuideline != null
     ? '${drug.userGuideline?.annotations.implication} '
       '${drug.userGuideline?.annotations.recommendation}'
-    : buildContext.l10n.drugs_page_no_guidelines_text;
+    : buildContext.l10n.drugs_page_no_guidelines_recommendation_text;
   return [
     _buildSubheading(buildContext.l10n.pdf_heading_user_data),
     _buildTextBlockSpacer(),

diff --git a/app/lib/drug/widgets/annotation_cards/guideline.dart b/app/lib/drug/widgets/annotation_cards/guideline.dart
@@ -94,7 +94,7 @@ class GuidelineAnnotationCard extends StatelessWidget {
                     WidgetSpan(child: SizedBox(height: PharMeTheme.mediumSpace * 1.3)),
                     TextSpan(
                       text:
-                        implicationText ?? context.l10n.drugs_page_no_guidelines_text,
+                        implicationText ?? context.l10n.drugs_page_no_guidelines_recommendation_text,
                       style: drug.warningLevel != WarningLevel.none
                         ? TextStyle(fontWeight: FontWeight.bold)
                         : TextStyle(fontStyle: FontStyle.italic)

diff --git a/app/lib/l10n/app_en.arb b/app/lib/l10n/app_en.arb
@@ -279,8 +279,20 @@
   },
   "drugs_page_header_guideline": "Gene-based clinical guideline",
   "@drugs_page_header_guideline": {},
-  "drugs_page_no_guidelines_text": "Standard dosing may apply; no recommendation based on your genes can be made at this time. Consult your pharmacist or doctor for more information.",
-  "@drugs_page_no_guidelines_text": {},
+  "drugs_page_no_guidelines_recommendation_text": "Standard dosing may apply; no recommendation based on your genes can be made at this time. Consult your pharmacist or doctor for more information.",
+  "@drugs_page_no_guidelines_recommendation_text": {
+    "description": "This should resemble the 'none' recommendation text from Anni"
+  },
+  "drugs_page_fda_indeterminate_implication_text": "More information is needed to comment on your genes' influence on {drugName}. We will keep you informed when the guidelines are updated.",
+  "@drugs_page_fda_indeterminate_implication_text": {
+    "description": "This should resemble the 'none' implication text from Anni",
+    "placeholders": {
+      "drugName": {
+        "type": "String",
+        "example": "ibuprofen"
+      }
+    }
+  },
   "drugs_page_sources_description": "Tap here to view the full expert guideline published by {source}",
   "@drugs_page_sources_description": {
       "placeholders": {